Reactive arthritis following BCG immunotherapy for bladder carcinoma

Intravesical instillation of bacillus Calmette-Guérin (BCG) is used in the treatment of patients with intermediate and high-risk superficial bladder carcinoma with efficacy and safety. The vast majority of patients do not present any side effects and only 5% of patients have mild and short-lived cli...

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Bibliographic Details
Published in:Clinical rheumatology 2005-08, Vol.24 (4), p.425-427
Main Authors: Tinazzi, Elisa, Ficarra, Vincenzo, Simeoni, Sara, Peterlana, Dimitri, Lunardi, Claudio
Format: Article
Language:English
Subjects:
Administration, Intravesical
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis
Arthritis, Reactive - drug therapy
Arthritis, Reactive - etiology
Arthritis, Reactive - physiopathology
BCG Vaccine - adverse effects
BCG Vaccine - therapeutic use
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - therapy
Drug therapy
Follow-Up Studies
Humans
Immunotherapy - adverse effects
Male
Neoplasm Staging
Risk Assessment
Treatment Outcome
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - therapy
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Summary:Intravesical instillation of bacillus Calmette-Guérin (BCG) is used in the treatment of patients with intermediate and high-risk superficial bladder carcinoma with efficacy and safety. The vast majority of patients do not present any side effects and only 5% of patients have mild and short-lived clinical manifestations such as malaise, low-grade fever, cystitis, and hematuria. Arthralgia and/or arthritis is one of the rare severe complications following intravesical BCG immunotherapy. We report here the case of a patient with reactive arthritis successfully treated with nonsteroidal anti-inflammatory drugs (NSAIDs) after the discontinuation of BCG immunotherapy.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-004-1063-8