Effects of nutrients on the production of AK-111-81 macrolide antibiotic by Streptomyces hygroscopicus

The influence of different carbon and nitrogen sources on the production of AK-111-81 nonpolyenic macrolide antibiotic by Streptomyces hygroscopicus 111-81 was studied. Substitution of glucose with lactose or glycerol significantly affected maximal antibiotic AK-111-81 productivity as the growth rat...

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Bibliographic Details
Published in:Microbiological research 2005-07, Vol.160 (3), p.243-248
Main Authors: Gesheva, V., Ivanova, V., Gesheva, R.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Carbon - metabolism
Culture Media - chemistry
Macrolides - metabolism
Nitrogen - metabolism
Nonpolyenic macrolide antibiotic
Nutrient effects
Streptomyces - growth & development
Streptomyces - metabolism
Streptomyces hygroscopicus
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Summary:The influence of different carbon and nitrogen sources on the production of AK-111-81 nonpolyenic macrolide antibiotic by Streptomyces hygroscopicus 111-81 was studied. Substitution of glucose with lactose or glycerol significantly affected maximal antibiotic AK-111-81 productivity as the growth rate was close to that of the basal fermentation medium. Addition of ammonium succinate to the fermentation medium markedly increased the antibiotic productivity as the growth rate was low. Divalent ions as Mn 2+, Cu 2+, Fe 2+ stimulated AK-111-81 antibiotic biosynthesis. These results allow us to develop a new fermentation medium showing 6-fold increase of AK-111-81 antibiotic formation compared with the basal fermentation medium.
ISSN:0944-5013
1618-0623
DOI:10.1016/j.micres.2004.06.005