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Effects of nutrients on the production of AK-111-81 macrolide antibiotic by Streptomyces hygroscopicus
The influence of different carbon and nitrogen sources on the production of AK-111-81 nonpolyenic macrolide antibiotic by Streptomyces hygroscopicus 111-81 was studied. Substitution of glucose with lactose or glycerol significantly affected maximal antibiotic AK-111-81 productivity as the growth rat...
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| Published in: | Microbiological research 2005-07, Vol.160 (3), p.243-248 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c484t-917e22964e65895428a383a52eadcb46dc66ce8ef92dd72876f6bdeeaf2b46193 |
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| cites | cdi_FETCH-LOGICAL-c484t-917e22964e65895428a383a52eadcb46dc66ce8ef92dd72876f6bdeeaf2b46193 |
| container_end_page | 248 |
| container_issue | 3 |
| container_start_page | 243 |
| container_title | Microbiological research |
| container_volume | 160 |
| creator | Gesheva, V. Ivanova, V. Gesheva, R. |
| description | The influence of different carbon and nitrogen sources on the production of AK-111-81 nonpolyenic macrolide antibiotic by
Streptomyces hygroscopicus 111-81 was studied. Substitution of glucose with lactose or glycerol significantly affected maximal antibiotic AK-111-81 productivity as the growth rate was close to that of the basal fermentation medium. Addition of ammonium succinate to the fermentation medium markedly increased the antibiotic productivity as the growth rate was low. Divalent ions as Mn
2+, Cu
2+, Fe
2+ stimulated AK-111-81 antibiotic biosynthesis. These results allow us to develop a new fermentation medium showing 6-fold increase of AK-111-81 antibiotic formation compared with the basal fermentation medium. |
| doi_str_mv | 10.1016/j.micres.2004.06.005 |
| format | article |
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Streptomyces hygroscopicus 111-81 was studied. Substitution of glucose with lactose or glycerol significantly affected maximal antibiotic AK-111-81 productivity as the growth rate was close to that of the basal fermentation medium. Addition of ammonium succinate to the fermentation medium markedly increased the antibiotic productivity as the growth rate was low. Divalent ions as Mn
2+, Cu
2+, Fe
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Streptomyces hygroscopicus 111-81 was studied. Substitution of glucose with lactose or glycerol significantly affected maximal antibiotic AK-111-81 productivity as the growth rate was close to that of the basal fermentation medium. Addition of ammonium succinate to the fermentation medium markedly increased the antibiotic productivity as the growth rate was low. Divalent ions as Mn
2+, Cu
2+, Fe
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2+, Cu
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| fulltext | fulltext |
| identifier | ISSN: 0944-5013 |
| ispartof | Microbiological research, 2005-07, Vol.160 (3), p.243-248 |
| issn | 0944-5013 1618-0623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68061874 |
| source | Elsevier |
| subjects | Anti-Bacterial Agents - biosynthesis Carbon - metabolism Culture Media - chemistry Macrolides - metabolism Nitrogen - metabolism Nonpolyenic macrolide antibiotic Nutrient effects Streptomyces - growth & development Streptomyces - metabolism Streptomyces hygroscopicus |
| title | Effects of nutrients on the production of AK-111-81 macrolide antibiotic by Streptomyces hygroscopicus |
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