Lipid-Derived Modifications of Plasma Proteins in Experimental and Human Diabetes

: Plasma from two diabetic rat models and human diabetic patients was analyzed to investigate the hypothesis that enhanced oxidative stress in diabetes promotes lipid‐derived protein modification. We evaluated the nonenzymatic modification of plasma protein by oxidized phospholipids, including measu...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-06, Vol.1043 (1), p.404-412
Main Authors: JANUSZEWSKI, ANDRZEJ S., JENKINS, ALICIA J., BAYNES, JOHN W., THORPE, SUZANNE R.
Format: Article
Language:English
Subjects:
Animals
Blood Proteins - metabolism
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus, Experimental - blood
Fatty acids
Female
Glutarates - pharmacology
Human
Humans
lipid peroxidation
Lipoproteins - blood
Oxidation
Patients
Phospholipids
protein modifications
Proteins
Rats
Rats, Sprague-Dawley
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Summary:: Plasma from two diabetic rat models and human diabetic patients was analyzed to investigate the hypothesis that enhanced oxidative stress in diabetes promotes lipid‐derived protein modification. We evaluated the nonenzymatic modification of plasma protein by oxidized phospholipids, including measurement of protein‐bound pentanedioate, nonanedioate, and hexanoate, all derived from oxidation of phospholipid polyunsaturated fatty acids. Generally pentanedioate was higher in diabetic compared with nondiabetic control groups, and nonanedioate was also higher in the diabetic rat models. We conclude that diabetes is associated with higher levels of phospholipid‐derived protein modification in both animal models and human diabetes. Their role in the development of diabetes vascular complications warrants further research.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1333.047