Use of ultra-performance liquid chromatography in pharmaceutical development

Ultra-performance liquid chromatography (UPLC) has been investigated as an alternative to HPLC for the analysis of pharmaceutical development compounds. We present data on three compounds showing that significant reductions in separation time can be achieved without compromising the separation quali...

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Bibliographic Details
Published in:Journal of Chromatography A 2006-06, Vol.1119 (1), p.140-146
Main Authors: Wren, Stephen A.C., Tchelitcheff, Pierre
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Chromatography, High Pressure Liquid - methods
General pharmacology
Medical sciences
Pharmaceutical development
Pharmaceutical Preparations - isolation & purification
Pharmacology. Drug treatments
Ultra performance liquid chromatography
UPLC
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Summary:Ultra-performance liquid chromatography (UPLC) has been investigated as an alternative to HPLC for the analysis of pharmaceutical development compounds. We present data on three compounds showing that significant reductions in separation time can be achieved without compromising the separation quality. Results from precision and comparative studies indicate that UPLC is a suitable technique for routine pharmaceutical analysis.
ISSN:0021-9673
DOI:10.1016/j.chroma.2006.02.052