Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature

Plasmablastic lymphoma is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity and jaws. The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic...

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Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2005-08, Vol.100 (2), p.198-206
Main Authors: Scheper, Mark A., Nikitakis, Nikolaos G., Fernandes, Rui, Gocke, Christopher D., Ord, Robert A., Sauk, John J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dentistry
Hematologic and hematopoietic diseases
HIV Seronegativity
Humans
Immunoglobulin G - analysis
Immunoglobulin lambda-Chains - analysis
Immunohistochemistry
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell - pathology
Lymphoma, Large B-Cell, Diffuse - pathology
Male
Mandibular Neoplasms - pathology
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Plasma Cells
Viral Matrix Proteins - analysis
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Summary:Plasmablastic lymphoma is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity and jaws. The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic and immunohistochemical phenotype of this lymphoma. Histopathologically, our case exhibited a dense, diffuse lymphocytic infiltrate of noncohesive large lymphocytes with plasmacytoid features. Immunohistochemical analysis revealed positivity for the B-cell marker CD79a, VS38c, Epstein-Barr virus latent membrane protein (LMP), immunoglobulin G (IgG), and lambda light chain restriction. Neoplastic cells were negative for leukocyte common antigen, CD20, CD3, CD10, CD138, Bcl-2, Bcl-6, desmin, actin, EMA, S-100, HMB45, Alk-1, HHV8, IgA, IgM, and cytokeratin. The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2004.11.050