Human chorionic gonadotropin (hCG) may be a marker of systemic oxidative stress in normotensive and preeclamptic term pregnancies

In vitro studies on placental function have revealed interactions between levels of secretion of human chorionic gonadotropin (hCG) by trophoblastic cells and oxidative stress generated by hydrogen peroxide (H 2O 2). Here, we have examined the relationship between maternal levels of hCG and H 2O 2 i...

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Bibliographic Details
Published in:Clinical biochemistry 2005-08, Vol.38 (8), p.717-721
Main Authors: Kharfi, Abdelaziz, Giguère, Yves, De Grandpré, Pierre, Moutquin, Jean-Marie, Forest, Jean-Claude
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Chorionic Gonadotropin - blood
Chorionic Gonadotropin, beta Subunit, Human - blood
Female
H 2O 2
hCG
Humans
Hydrogen Peroxide - blood
Oxidative stress
Oxidative Stress - physiology
Pre-Eclampsia - physiopathology
Preeclampsia
Pregnancy
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Summary:In vitro studies on placental function have revealed interactions between levels of secretion of human chorionic gonadotropin (hCG) by trophoblastic cells and oxidative stress generated by hydrogen peroxide (H 2O 2). Here, we have examined the relationship between maternal levels of hCG and H 2O 2 in vivo in term pregnancies with and without preeclampsia. We measured serum levels of hCG and H 2O 2 in twenty preeclamptic and twenty normotensive term pregnant women (controls), using an enzymatic immunoassay and an electrochemical method, respectively. Higher levels of serum hCG and H 2O 2 were observed in patients with preeclampsia in comparison to controls. A significant positive correlation between serum hCG concentration and H 2O 2 production was found. Our results show that: (1) systemic hCG levels are correlated with an oxidative stress state in term pregnant women with preeclampsia and (2) circulating hCG may be a monitoring tool of oxidative stress during pregnancy.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2005.04.011