Therapeutic potential of CD4+ CD25+ regulatory T cells in allogeneic transplantation

The subpopulation of CD4 CD25 immunoregulatory T cells constitutes less than of the entire CD4 T-cell pool in mice and in humans. These cells play a crucial role in the control of autoimmune processes. More recently, in vitro and in vivo data also indicate that CD4 CD25 immunoregulatory T cells can...

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Bibliographic Details
Published in:Cytotherapy (Oxford, England) England), 2005-05, Vol.7 (2), p.166-170
Main Authors: Cohen, J.L., Salomon, B.L.
Format: Article
Language:English
Subjects:
Animals
APC
CD4+ CD25+ immunoregulatory T cells (Treg)
CD4-Positive T-Lymphocytes - immunology
Graft vs Host Disease - immunology
GvHD
Hematopoietic Stem Cell Transplantation
hematopoietic stem cell transplantation (HSCT)
Humans
Immunosuppression
Mice
Organ Transplantation
Receptors, Interleukin-2 - immunology
T-Lymphocyte Subsets - immunology
Transplantation, Homologous
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Summary:The subpopulation of CD4 CD25 immunoregulatory T cells constitutes less than of the entire CD4 T-cell pool in mice and in humans. These cells play a crucial role in the control of autoimmune processes. More recently, in vitro and in vivo data also indicate that CD4 CD25 immunoregulatory T cells can regulate alloreactivity. This renders them good candidates for innovative strategies in the field of transplantation. Inducing a state of immune tolerance with immunoregulatory T cells would alleviate the need for immunosuppression, and the occurrence of late allograft failure represents a major goal of transplantation immunology. Here we discuss how these naturally occurring CD4 CD25 immunoregulatory T cells can be used to modulate alloreactivity in hematopoietic stem cell and solid organ transplantation.
ISSN:1465-3249
1477-2566
DOI:10.1080/14653240510018145