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Decrease in Epstein–Barr virus-positive AIDS-related lymphoma in the era of highly active antiretroviral therapy

Recent introduction of highly active antiretroviral therapy (HAART) is reported to have reduced the incidence of lymphoma among HIV-infected individuals. A clinicopathological study was performed on 86 AIDS-related lymphoma patients who were treated in Tokyo area from 1987 to 2005. The incidence of...

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Published in:Microbes and infection 2006-04, Vol.8 (5), p.1301-1307
Main Authors: Hishima, Tsunekazu, Oyaizu, Naoki, Fujii, Takeshi, Tachikawa, Natsuo, Ajisawa, Atsushi, Negishi, Masayoshi, Nakamura, Tetsuya, Iwamoto, Aikichi, Hayashi, Yukiko, Matsubara, Daisuke, Sasao, Yuki, Kimura, Satoshi, Kikuchi, Yoshimi, Teruya, Katsuji, Yasuoka, Akira, Oka, Shinichi, Saito, Kiyoshi, Mori, Shigeo, Funata, Nobuaki, Sata, Tetsutaro, Katano, Harutaka
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cited_by cdi_FETCH-LOGICAL-c533t-b0032befe4460bbf75c61eb4d236c813562022f88c2c2138ab60b274317dd8493
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creator Hishima, Tsunekazu
Oyaizu, Naoki
Fujii, Takeshi
Tachikawa, Natsuo
Ajisawa, Atsushi
Negishi, Masayoshi
Nakamura, Tetsuya
Iwamoto, Aikichi
Hayashi, Yukiko
Matsubara, Daisuke
Sasao, Yuki
Kimura, Satoshi
Kikuchi, Yoshimi
Teruya, Katsuji
Yasuoka, Akira
Oka, Shinichi
Saito, Kiyoshi
Mori, Shigeo
Funata, Nobuaki
Sata, Tetsutaro
Katano, Harutaka
description Recent introduction of highly active antiretroviral therapy (HAART) is reported to have reduced the incidence of lymphoma among HIV-infected individuals. A clinicopathological study was performed on 86 AIDS-related lymphoma patients who were treated in Tokyo area from 1987 to 2005. The incidence of lymphoma detected by autopsy was 27% (53 cases/198 autopsies). Diffuse large B cell lymphoma was the most predominant histological subtype throughout the period (78%). Burkitt's lymphoma (BL) increased from 2% in the pre-HAART era (before end-1997) to 13% in the HAART era, whereas incidence of BL did not vary between HAART users and non-users. Epstein–Barr virus (EBV)-positive lymphoma decreased from 88% in the pre-HAART era to 58% in the HAART era, but did not differ significantly between HAART users (73%) and non-users (74%). Nodal involvement of lymphoma increased from 14% in the pre-HAART era to 50% in the HAART era; however, central nervous system involvement decreased from 62 to 38%. Kaposi's sarcoma-associated herpesvirus infection was rare (4%) among all cases. These data suggest that HAART might play a partial role in these changes, and the alteration in immunological backgrounds, such as EBV prevalence, is suggested as another leading cause of these changes in Japanese AIDS-related lymphoma.
doi_str_mv 10.1016/j.micinf.2005.12.012
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A clinicopathological study was performed on 86 AIDS-related lymphoma patients who were treated in Tokyo area from 1987 to 2005. The incidence of lymphoma detected by autopsy was 27% (53 cases/198 autopsies). Diffuse large B cell lymphoma was the most predominant histological subtype throughout the period (78%). Burkitt's lymphoma (BL) increased from 2% in the pre-HAART era (before end-1997) to 13% in the HAART era, whereas incidence of BL did not vary between HAART users and non-users. Epstein–Barr virus (EBV)-positive lymphoma decreased from 88% in the pre-HAART era to 58% in the HAART era, but did not differ significantly between HAART users (73%) and non-users (74%). Nodal involvement of lymphoma increased from 14% in the pre-HAART era to 50% in the HAART era; however, central nervous system involvement decreased from 62 to 38%. Kaposi's sarcoma-associated herpesvirus infection was rare (4%) among all cases. 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ispartof Microbes and infection, 2006-04, Vol.8 (5), p.1301-1307
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subjects Adolescent
Adult
Aged
AIDS-related lymphoma
Antiretroviral Therapy, Highly Active
Biological and medical sciences
Burkitt Lymphoma - epidemiology
Burkitt's lymphoma
Child
Diffuse large B cell lymphoma
Epstein-Barr virus
Epstein-Barr Virus Infections - epidemiology
Epstein-Barr Virus Infections - virology
Female
Fundamental and applied biological sciences. Psychology
Herpesvirus 4, Human
Highly active antiretroviral therapy
HIV Infections - complications
HIV Infections - drug therapy
Human herpesvirus 8
Human immunodeficiency virus
Human viral diseases
Humans
Incidence
Infectious diseases
Japan - epidemiology
Lymphoma, AIDS-Related - epidemiology
Lymphoma, AIDS-Related - virology
Lymphoma, B-Cell - epidemiology
Lymphoma, Large B-Cell, Diffuse - epidemiology
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
title Decrease in Epstein–Barr virus-positive AIDS-related lymphoma in the era of highly active antiretroviral therapy
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