A Newly Discovered Fc Receptor that Explains IgG-Isotype Disparities in Effector Responses

The known IgG FcRs primarily mediate inflammation by interacting with IgG1, even though IgG2 isotypes tend to be more pathogenic. Nimmerjahn et al. (2005) have just identified a novel FcγR that binds IgG2 but not IgG1, potentially explaining differences in biological activity that are seen with vari...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2005-07, Vol.23 (1), p.2-4
Main Author: Bolland, Silvia
Format: Article
Language:English
Subjects:
Animals
Arthritis
Autoimmune diseases
Binding sites
Blood platelets
Cytotoxicity
Disease
Humans
Immune system
Immunoglobulin Allotypes - immunology
Immunoglobulin G - immunology
Immunoglobulin G - metabolism
Lymphocytes
Mice
Receptors, IgG - genetics
Receptors, IgG - metabolism
Rodents
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Summary:The known IgG FcRs primarily mediate inflammation by interacting with IgG1, even though IgG2 isotypes tend to be more pathogenic. Nimmerjahn et al. (2005) have just identified a novel FcγR that binds IgG2 but not IgG1, potentially explaining differences in biological activity that are seen with various IgG isotypes ( Nimmerjahn et al., 2005).
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2005.07.002