Role of diffusion-weighted MR imaging in cervical lymphadenopathy

The role of diffusion-weighted magnetic resonance imaging (MRI) for differentiation between various causes of cervical lymphadenopathy was evaluated. In a prospective study, 31 untreated patients (22 males and nine females, aged 5-70 years) with 87 cervical lymph nodes underwent diffusion-weighted M...

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Bibliographic Details
Published in:European radiology 2006-07, Vol.16 (7), p.1468-1477
Main Authors: Abdel Razek, Ahmed Abdel Khalek, Soliman, Nermin Yehia, Elkhamary, Sahar, Alsharaway, Mousa K, Tawfik, Ali
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Benign
Biopsy
Child
Child, Preschool
Diffusion coefficient
Diffusion Magnetic Resonance Imaging - methods
Female
Functional magnetic resonance imaging
Humans
Image acquisition
Image Enhancement - methods
Image reconstruction
Lymph nodes
Lymph Nodes - pathology
Lymphadenopathy
Lymphatic Diseases - diagnosis
Lymphatic system
Magnetic resonance imaging
Male
Medical imaging
Metastases
Middle Aged
Neck
Reproducibility of Results
Sensitivity and Specificity
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Summary:The role of diffusion-weighted magnetic resonance imaging (MRI) for differentiation between various causes of cervical lymphadenopathy was evaluated. In a prospective study, 31 untreated patients (22 males and nine females, aged 5-70 years) with 87 cervical lymph nodes underwent diffusion-weighted MRI before performance of neck dissection (n=14), surgical biopsy (n=9) or core biopsy (n=8). Diffusion-weighted MR images were acquired with a b factor of 0 and 1,000 s/mm2 using single-shot echo-planar sequence. Apparent diffusion coefficient (ADC) maps were reconstructed for all patients. The signal intensity of the lymph nodes was assessed on images obtained at b=0 or 1,000 s/mm2 and from the ADC maps. The ADC value of lymph nodes was also calculated. On the ADC map, malignant nodes showed either low (n=52) or mixed (n=20) signal intensity and benign nodes revealed high (n=13) or low (n=2) signal intensity. The mean ADC value of metastatic (1.09+/-0.11x10(-3) mm2/s) and lymphomatous (0.97+/-0.27x10(-3) mm2/s) lymph nodes was significantly lower than that of benign (1.64+/-0.16x10(-3) mm2/s) cervical lymph nodes (P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-005-0133-x