The expressions of insulin-like growth factors, their receptors, and binding proteins are related to the mechanism regulating masseter muscle mass in the rat

The mechanism regulating skeletal muscle mass is unclear. The purpose of the present study was to investigate the extent to which insulin-like growth factors (IGFs), their receptors (IGFRs), and binding proteins (IGFBPs) are involved in the regulation of skeletal muscle mass. We measured the mRNA ex...

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Bibliographic Details
Published in:Archives of oral biology 2006-07, Vol.51 (7), p.603-611
Main Authors: Matsumoto, T., Akutsu, S., Wakana, N., Morito, M., Shimada, A., Yamane, A.
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacology
Animals
Clenbuterol
Clenbuterol - pharmacology
Competitive RT-PCR
Dentistry
Hypertrophy - chemically induced
IGFs
Insulin-Like Growth Factor Binding Proteins - metabolism
Male
Masseter muscle
Masseter Muscle - anatomy & histology
Masseter Muscle - drug effects
Masseter Muscle - metabolism
Muscle, Skeletal - anatomy & histology
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Rat
Rats
Receptors, Somatomedin - metabolism
RNA, Messenger - metabolism
Somatomedins - metabolism
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Summary:The mechanism regulating skeletal muscle mass is unclear. The purpose of the present study was to investigate the extent to which insulin-like growth factors (IGFs), their receptors (IGFRs), and binding proteins (IGFBPs) are involved in the regulation of skeletal muscle mass. We measured the mRNA expression levels for IGFs, IGFRs, and IGFBPs in the rat masseter muscle hypertrophied by oral administration of clenbuterol for 3 weeks and determined the correlations between the weight of masseter muscle and the mRNA expression levels. The mRNA expression levels for IGF-I and II, IGFR1 and 2, and IGFBP4 and 6 showed clenbuterol-induced elevations and positive correlations with the weight of masseter muscle. That for IGFBP3 only exhibited a clenbuterol-induced decrease and a strong negative correlation with the weight of masseter muscle. The mRNA expression levels for IGFBP2 and 5 showed no significant changes between the control and clenbuterol groups, and no significant correlations. IGFBP1 mRNA was not detectable. These results suggest that IGF-I, II, IGFR1 and 2, and IGFBP3, 4 and 6 are related to the mechanism regulating masseter muscle mass in the rat.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2006.01.003