Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

Toll-like receptor 4 (TLR4) is a receptor for bacterial lipopolysaccharide, which is suggested to be involved in the pathogenesis of disease of hepatobiliary tracts. To explore a possible role for this receptor in primary biliary cirrhosis (PBC), we investigated the expression of TLR4 in liver tissu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of autoimmunity 2005-08, Vol.25 (1), p.85-91
Main Authors: Wang, Ai-Ping, Migita, Kiyoshi, Ito, Masahiro, Takii, Yasushi, Daikoku, Manabu, Yokoyama, Terufumi, Komori, Atsumasa, Nakamura, Minoru, Yatsuhashi, Hiroshi, Ishibashi, Hiromi
Format: Article
Language:English
Subjects:
Bile duct epithelial cells
Bile Ducts - metabolism
Bile Ducts - pathology
Biological and medical sciences
Disease Progression
Epithelium - metabolism
Epithelium - pathology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects
Humans
Immunopathology
Lipopolysaccharide
Liver - metabolism
Liver - pathology
Liver Cirrhosis, Biliary - genetics
Liver Cirrhosis, Biliary - metabolism
Liver Cirrhosis, Biliary - pathology
Medical sciences
Membrane Glycoproteins - biosynthesis
Membrane Glycoproteins - genetics
Primary biliary cirrhosis
Receptors, Cell Surface - biosynthesis
Receptors, Cell Surface - genetics
Toll-Like Receptor 4
Toll-Like Receptors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Toll-like receptor 4 (TLR4) is a receptor for bacterial lipopolysaccharide, which is suggested to be involved in the pathogenesis of disease of hepatobiliary tracts. To explore a possible role for this receptor in primary biliary cirrhosis (PBC), we investigated the expression of TLR4 in liver tissues from PBC patients. We studied liver biopsy sections from 62 PBC patients and 41 patients with chronic hepatitis C (CHC). Expression of TLR4 in paraffin-embedded sections was analyzed by immunohistochemistry. The bile duct epithelial cells (BECs) of PBC liver tissues markedly expressed TLR4, whereas BECs of CHC liver tissues barely expressed TLR4. The TLR4 expression was also observed in periportal hepatocytes of PBC liver tissues and its expression was extended to interlobular hepatocytes in advanced stage PBC. Although periportal hepatocytes of CHC liver tissues expressed TLR4, its expression levels were not correlated with the fibrosis stage. Our data demonstrated that TLR4 was expressed in BECs and periportal hepatocytes in PBC livers, suggesting the possible involvement of bacterial pathogens and TLR4 in the inflammatory processes of PBC.
ISSN:0896-8411
1095-9157
DOI:10.1016/j.jaut.2005.05.003