High-density doxorubicin-conjugated polymeric nanoparticles via ring-opening metathesis polymerization

High-density doxorubicin-conjugated polymeric nanoparticles are prepared via ring-opening metathesis polymerization and sustained release of nearly 50% of the anticancer agent is observed after 24 h in mildly acidic aqueous solution.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-08 (30), p.3793-3795
Main Authors: Bertin, Paul A, Smith, DeeDee, Nguyen, SonBinh T
Format: Article
Language:English
Subjects:
Doxorubicin - chemical synthesis
Doxorubicin - chemistry
Hydrogen-Ion Concentration
Microscopy, Electron, Transmission
Molecular Structure
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Polymers - chemistry
Solutions
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Description
Summary:High-density doxorubicin-conjugated polymeric nanoparticles are prepared via ring-opening metathesis polymerization and sustained release of nearly 50% of the anticancer agent is observed after 24 h in mildly acidic aqueous solution.
ISSN:1359-7345
1364-548X
DOI:10.1039/b504643b