Skull base approaches in the pediatric population

• Published in: Head & neck 2005-08, Vol.27 (8), p.682-689
• Main Authors: Gil, Ziv, Constantini, Shlomo, Spektor, Sergey, Abergel, Avraham, Khafif, Avi, Beni-Adani, Liana, Leonor, Trejo-Leider, DeRowe, Ari, Fliss, Dan M.
• Format: Article
• Language: English
• Subjects: Adolescent; Biological and medical sciences; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - surgery; Child; Child, Preschool; children; Cohort Studies; Female; Humans; Infant; Male; malignant tumors; Medical sciences; nasal cavity; Otorhinolaryngology. Stomatology; paranasal sinuses; Retrospective Studies; skull base; Skull Base - surgery; Skull Base Neoplasms - mortality; Skull Base Neoplasms - surgery; subcranial approach; Survival Rate; Treatment Outcome
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.20226

Background. This study aimed to examine the surgical, oncologic, and developmental results of infants and children undergoing extirpation of skull base tumors. Methods. Sixty‐seven children aged 0.5 to 18 years (mean, 11 years) who were operated on during a 6‐year period made up the study cohort. Eighteen cases (27%) involved malignant tumors, and 49 (73%) involved benign tumors. The most common benign tumors were craniopharyngioma (n = 10) and juvenile nasopharyngeal angiofibroma (n = 8). The most common malignant tumor was sarcoma (n = 5). Thirty‐six tumors (55%) involved the anterior skull base, and the rest involved the lateral (n = 24) and posterior (n = 7) skull base. Subcranial, transfacial, and subfrontal approaches were used for extirpation of anterior skull base tumors. Voluminous or malignant tumors were excised by use of combined approaches (subcranial‐transfacial, subcranial‐degloving, or pterional‐degloving). Twenty‐two children underwent adjuvant therapy (chemotherapy, radiation, or both). Postoperative follow‐up was 3 to 60 months. Results. No severe postoperative complications (ie, meningitis, cerebrospinal fluid leak, tension pneumocephalus) and no perioperative mortality occurred. Two and a half years later, 54 of the children (80%) are alive and well. Five children, two with optic glioma and one each with squamous cell carcinoma, ependymoma, and germinoma, have died of their disease. The subcranial approach had no cosmetic impact on the craniofacial development of the patients. Conclusion. The extirpation of skull base tumors by use of conventional surgical techniques is feasible and safe among infants and children. The complication and mortality rates are lower than those in adults. The long‐term cosmetic effect of the subcranial approach is negligible. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005