Sterically-controlled regioselective para-substitutions of aniline

Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-08 (30), p.3835-3837
Main Authors: Dyer, Philip W, Fawcett, John, Griffith, Gerald A, Hanton, Martin J, Olivier, Céline, Patterson, Adam R, Suhard, Samuel
Format: Article
Language:English
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Summary:Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.
ISSN:1359-7345
1364-548X
DOI:10.1039/b506824j