Immunomodulation after allogeneic bone marrow transplantation by CD4 +CD25 + regulatory T cells

Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation (BMT) caused by donor T cells. Immunosuppression mediated by CD4 +CD25 + regulatory T cells has been shown to ameliorate such pathogenic immune responses in animal models. Here, we summarize recent finding...

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Bibliographic Details
Published in:Microbes and infection 2005-06, Vol.7 (7), p.1066-1072
Main Authors: Hoffmann, Petra, Boeld, Tina J., Piseshka, Biserka, Edinger, Matthias
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Transplantation - immunology
CD4-Positive T-Lymphocytes - physiology
Graft vs Host Disease - immunology
Graft-versus-host disease
Humans
Immune Tolerance
Leukemia
Receptors, Interleukin-2 - physiology
Tolerance
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Summary:Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation (BMT) caused by donor T cells. Immunosuppression mediated by CD4 +CD25 + regulatory T cells has been shown to ameliorate such pathogenic immune responses in animal models. Here, we summarize recent findings from experimental and clinical studies and propose a model for peripheral tolerance induction after BMT.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2005.03.035