Infiltrative Trichilemmal Carcinoma Treated with 5% Imiquimod Cream

BACKGROUNDTrichilemmal carcinoma (TLC) is a rare cutaneous neoplasm that occurs in the sun-exposed skin of the elderly. Although the clinical behavior of TLC appears to be relatively indolent, wide excision or Mohs micrographic surgery is the recommended treatment owing to its locally aggressive gro...

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Bibliographic Details
Published in:Dermatologic surgery 2005-08, Vol.31 (8), p.973-976
Main Authors: Jo, Ju-Hyun, Ko, Hyun-Chang, Jang, Ho-Sun, Kim, Moon-Bum, Oh, Chang-Keun, Kwon, Kyung-Sool
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Aged
Aged, 80 and over
Aminoquinolines - administration & dosage
Antineoplastic Agents - administration & dosage
Biological and medical sciences
Dermatology
Diagnosis, Differential
Face - pathology
Female
General aspects
Hair Follicle - pathology
Humans
Imiquimod
Medical sciences
Skin Neoplasms - diagnosis
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
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Summary:BACKGROUNDTrichilemmal carcinoma (TLC) is a rare cutaneous neoplasm that occurs in the sun-exposed skin of the elderly. Although the clinical behavior of TLC appears to be relatively indolent, wide excision or Mohs micrographic surgery is the recommended treatment owing to its locally aggressive growth. Recently, imiquimod has become an important part of the armamentarium in the treatment of nonmelanoma skin cancer. OBJECTIVEThis article serves to remind dermatologists that in addition to Mohs micrographic surgery and surgical excision, imiquimod 5% cream may have a role in the treatment of TLC. METHODSIn addition to a review of the literature, we present a case of TLC successfully treated with 5% imiquimod cream. CONCLUSIONIts nonsurgical approach and excellent cosmetic result make imiquimod 5% cream another promising therapeutic option for TLC, even though it is histologically infiltrative.
ISSN:1076-0512
1524-4725
DOI:10.1097/00042728-200508000-00016