Age‐specific reference levels of serum prostate‐specific antigen and prostate volume in healthy Arab men

• Published in: BJU international 2005-08, Vol.96 (3), p.308-312
• Main Authors: Kehinde, Elijah O., Mojiminiyi, Olusegun A., Sheikh, Mehraj, Al‐Awadi, Kaleel A., Daar, Abdallah S., Al‐Hunayan, Adel, Anim, Jehoram T., Al‐Sumait, Aisha A.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Arab; Arabs; Asian; Biological and medical sciences; Caucasian; Genital system. Mammary gland; Humans; Investigative techniques, diagnostic techniques (general aspects); Kuwait - ethnology; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Oman - ethnology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prostate - anatomy & histology; prostate volume; Prostate-Specific Antigen - blood; prostate‐specific antigen; Prostatic Neoplasms - blood; Prostatic Neoplasms - ethnology; Prostatic Neoplasms - pathology; Reference Values
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1111/j.1464-410X.2005.05620.x

OBJECTIVE To determine age‐specific reference ranges for serum prostate‐specific antigen (PSA) concentration and prostate volumes in a population of healthy Arab men. SUBJECTS AND METHODS Blood samples were taken from 396 healthy Arab men (from Kuwait and Oman) aged 15–79 years and from across the social spectrum. Men aged >40 years had a digital rectal examination and transrectal ultrasonography of the prostate to determine prostate volume. The serum PSA level was measured using commercial kits, and age‐specific ranges for PSA levels and prostate volume determined. RESULTS The serum PSA ranges (ng/mL) for each age range in Arab men were: 40–49 years, 0–0.9; 60–69, 0–2.7; 70–79, 0–5.5 ng/mL; the respective prostate volumes were 8–22, 9–30 and 10–33 mL. The serum PSA level and prostate volume correlated with age (P