Oxidative stress response to aerobic exercise : Comparison of antioxidant supplements

• Published in: Medicine and science in sports and exercise 2006-06, Vol.38 (6), p.1098-1105
• Main Authors: BLOOMER, Richard J, GOLDFARB, Allan H, MCKENZIE, Michael J
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants - therapeutic use; Ascorbic Acid - blood; Ascorbic Acid - therapeutic use; Biological and medical sciences; Biomarkers - blood; Blood Proteins - analysis; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - blood; Dietary Supplements; Double-Blind Method; Female; Fruit; Fundamental and applied biological sciences. Psychology; Humans; Male; Malondialdehyde - blood; Oxidative Stress - drug effects; Oxygen Consumption - physiology; Physical Exertion - physiology; Placebos; Powders; Protein Carbonylation; Space life sciences; Vegetables; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Vitamin A - therapeutic use; Vitamin E - blood; Vitamin E - therapeutic use
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/01.mss.0000222839.51144.3e

To compare the effects of two antioxidant formulas on biomarkers of oxidative stress before and after aerobic exercise. Aerobically trained men (N=25) and women (N=23) were assigned to one of three treatments: 400 IU of vitamin E+1 g of vitamin C (V; N=15), a fruit and vegetable juice powder concentrate (FV; N=16), or a placebo (P; N=17). Subjects ran for 30 min at 80% VO(2 max) before, after 2 wk of supplementation, and after a 1-wk washout period. Blood samples were taken before and immediately after exercise and analyzed for protein carbonyls (PC), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and vitamins C and E. The V treatment increased plasma vitamin C and E after 2 wk (P