Kallikrein–kinin system in hepatic experimental models

The purpose of this brief review is to describe some characteristics of the kallikrein–kinin system (KKS) in the liver. The liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in rats during the acute phase reaction. It is also the main organ to clear tissu...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2005-08, Vol.26 (8), p.1301-1307
Main Authors: Kouyoumdjian, Maria, Nagaoka, Márcia Regina, Borges, Durval Rosa
Format: Article
Language:English
Subjects:
ACE
Animals
Biological and medical sciences
Bradykinin
Bradykinin - metabolism
Bradykinin-receptor
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Galectin
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Kallikrein
Kallikrein-Kinin System - physiology
Kallikreins - metabolism
Liver - metabolism
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Other diseases. Semiology
Portal hypertension
Receptors, Cell Surface - metabolism
Vertebrates: endocrinology
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Summary:The purpose of this brief review is to describe some characteristics of the kallikrein–kinin system (KKS) in the liver. The liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in rats during the acute phase reaction. It is also the main organ to clear tissue as well as plasma kallikrein from the circulation in normal and pathological conditions. Bradykinin (BK), yielded by the kallikrein–kinin system, is a potent arterial hypotensive peptide, but in the liver it induces a portal hypertensive response. The portal hypertensive action of bradykinin is mediated by B 2 receptors located on sinusoidal cells of the periportal region and is followed by its hydrolysis by angiotensin-converting enzyme, which is primarily present in the perivenous (centrolobular) region.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2005.03.024