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Kallikrein–kinin system in hepatic experimental models
The purpose of this brief review is to describe some characteristics of the kallikrein–kinin system (KKS) in the liver. The liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in rats during the acute phase reaction. It is also the main organ to clear tissu...
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| Published in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2005-08, Vol.26 (8), p.1301-1307 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c396t-c2358620bfba5eda9af5794e488fb6861419411d9a78c4dd5d8cd35f89a164963 |
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| cites | cdi_FETCH-LOGICAL-c396t-c2358620bfba5eda9af5794e488fb6861419411d9a78c4dd5d8cd35f89a164963 |
| container_end_page | 1307 |
| container_issue | 8 |
| container_start_page | 1301 |
| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 26 |
| creator | Kouyoumdjian, Maria Nagaoka, Márcia Regina Borges, Durval Rosa |
| description | The purpose of this brief review is to describe some characteristics of the kallikrein–kinin system (KKS) in the liver. The liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in rats during the acute phase reaction. It is also the main organ to clear tissue as well as plasma kallikrein from the circulation in normal and pathological conditions. Bradykinin (BK), yielded by the kallikrein–kinin system, is a potent arterial hypotensive peptide, but in the liver it induces a portal hypertensive response. The portal hypertensive action of bradykinin is mediated by B
2 receptors located on sinusoidal cells of the periportal region and is followed by its hydrolysis by angiotensin-converting enzyme, which is primarily present in the perivenous (centrolobular) region. |
| doi_str_mv | 10.1016/j.peptides.2005.03.024 |
| format | article |
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2 receptors located on sinusoidal cells of the periportal region and is followed by its hydrolysis by angiotensin-converting enzyme, which is primarily present in the perivenous (centrolobular) region.</description><subject>ACE</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bradykinin</subject><subject>Bradykinin - metabolism</subject><subject>Bradykinin-receptor</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galectin</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Kallikrein</subject><subject>Kallikrein-Kinin System - physiology</subject><subject>Kallikreins - metabolism</subject><subject>Liver - metabolism</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Portal hypertension</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EoqXwC1U2sEuwE8exd6CKl0BiA2vLsSfCbV7YKaI7_oE_5Etw1aAuWc0szr0zOgjNCU4IJuxymfTQD9aAT1KM8wRnCU7pAZoSXmRxTpg4RFNMBItFwckEnXi_xBhTKvgxmhCGaSoKMkX8UdW1XTmw7c_X98q2to38xg_QRGF7g14NVkfw2YOzDbSDqqOmM1D7U3RUqdrD2Thn6PX25mVxHz893z0srp9inQk2xDrNcs5SXFalysEooaq8EBQo51XJOCOUCEqIEargmhqTG65NlldcKMKoYNkMXex6e9e9r8EPsrFeQ12rFrq1l4zjgofKALIdqF3nvYNK9uFl5TaSYLl1Jpfyz5ncOpM4k8FZCM7HC-uyAbOPjZICcD4CymtVV0612vo9V-AsmN1yVzsu6IEPC056baHVYKwDPUjT2f9--QXzMI6u</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Kouyoumdjian, Maria</creator><creator>Nagaoka, Márcia Regina</creator><creator>Borges, Durval Rosa</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Kallikrein–kinin system in hepatic experimental models</title><author>Kouyoumdjian, Maria ; Nagaoka, Márcia Regina ; Borges, Durval Rosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-c2358620bfba5eda9af5794e488fb6861419411d9a78c4dd5d8cd35f89a164963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ACE</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bradykinin</topic><topic>Bradykinin - metabolism</topic><topic>Bradykinin-receptor</topic><topic>Disease Models, Animal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galectin</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Kallikrein</topic><topic>Kallikrein-Kinin System - physiology</topic><topic>Kallikreins - metabolism</topic><topic>Liver - metabolism</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Portal hypertension</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouyoumdjian, Maria</creatorcontrib><creatorcontrib>Nagaoka, Márcia Regina</creatorcontrib><creatorcontrib>Borges, Durval Rosa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouyoumdjian, Maria</au><au>Nagaoka, Márcia Regina</au><au>Borges, Durval Rosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kallikrein–kinin system in hepatic experimental models</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>26</volume><issue>8</issue><spage>1301</spage><epage>1307</epage><pages>1301-1307</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>The purpose of this brief review is to describe some characteristics of the kallikrein–kinin system (KKS) in the liver. The liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in rats during the acute phase reaction. It is also the main organ to clear tissue as well as plasma kallikrein from the circulation in normal and pathological conditions. Bradykinin (BK), yielded by the kallikrein–kinin system, is a potent arterial hypotensive peptide, but in the liver it induces a portal hypertensive response. The portal hypertensive action of bradykinin is mediated by B
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| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2005-08, Vol.26 (8), p.1301-1307 |
| issn | 0196-9781 1873-5169 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | ACE Animals Biological and medical sciences Bradykinin Bradykinin - metabolism Bradykinin-receptor Disease Models, Animal Fundamental and applied biological sciences. Psychology Galectin Gastroenterology. Liver. Pancreas. Abdomen Humans Kallikrein Kallikrein-Kinin System - physiology Kallikreins - metabolism Liver - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Portal hypertension Receptors, Cell Surface - metabolism Vertebrates: endocrinology |
| title | Kallikrein–kinin system in hepatic experimental models |
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