A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia

Translocations involving 3q27 that affect the BCL6 gene are common and specific chromosomal abnormalities in B-cell precursor non-Hodgkin lymphoma (mainly diffuse large-cell and follicular lymphoma), but they have not been reported in Burkitt lymphoma. Here, we describe a case in which a BCL6 rearra...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2006-07, Vol.168 (1), p.69-72
Main Authors: Sandlund, John T., Kastan, Michael B., Kennedy, Wren, Behm, Frederick, Entrekin, Elaine, Pui, Ching-Hon, Kalwinsky, David T., Raimondi, Susana C.
Format: Article
Language:English
Subjects:
Ataxia Telangiectasia - complications
Ataxia Telangiectasia - genetics
Burkitt Lymphoma - complications
Burkitt Lymphoma - genetics
Child
Chromosomes, Human, Pair 3 - genetics
Chromosomes, Human, Pair 8 - genetics
DNA-Binding Proteins - genetics
Female
Genes, myc
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Proto-Oncogene Proteins c-bcl-6
Translocation, Genetic - genetics
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Summary:Translocations involving 3q27 that affect the BCL6 gene are common and specific chromosomal abnormalities in B-cell precursor non-Hodgkin lymphoma (mainly diffuse large-cell and follicular lymphoma), but they have not been reported in Burkitt lymphoma. Here, we describe a case in which a BCL6 rearrangement and additional complex cytogenetic abnormalities occurred in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Although cytogenetic analysis of the bone marrow revealed clonal abnormalities of chromosome arms 8q and 14p and other subclonal abnormalities, the t(8;14) or its variants typically associated with Burkitt lymphoma were not observed. Fluorescence in situ hybridization with locus-specific probes and multicolor spectral karyotyping demonstrated a complex pattern of chromosomal rearrangements leading to a subtle t(3;8)(q27;q24.1) that rearranged BCL6 and placed it adjacent to MYC. We speculate that this genetic lesion occurred as a result of chromosomal instability due to the underlying disease.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2005.12.013