Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI

We introduce MACACC-Mapping Anatomical Correlations Across Cerebral Cortex-to study correlated changes within and across different cortical networks. The principal topic of investigation is whether the thickness of one area of the cortex changes in a statistically correlated fashion with changes in...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006-07, Vol.31 (3), p.993-1003
Main Authors: Lerch, Jason P., Worsley, Keith, Shaw, W. Philip, Greenstein, Deanna K., Lenroot, Rhoshel K., Giedd, Jay, Evans, Alan C.
Format: Article
Language:English
Subjects:
Adolescent
Age
Brain
Brain Mapping - methods
Cerebral Cortex - anatomy & histology
Child
Child Development - physiology
Dominance, Cerebral - physiology
Female
Frontal Lobe - anatomy & histology
Humans
Image Processing, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Intelligence
Intelligence - physiology
Language
Linear Models
Magnetic Resonance Imaging - methods
Male
Mathematical Computing
Nerve Net - anatomy & histology
Older people
Parietal Lobe - anatomy & histology
Population
Software
Statistics as Topic
Studies
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Summary:We introduce MACACC-Mapping Anatomical Correlations Across Cerebral Cortex-to study correlated changes within and across different cortical networks. The principal topic of investigation is whether the thickness of one area of the cortex changes in a statistically correlated fashion with changes in thickness of other cortical regions. We further extend these methods by introducing techniques to test whether different population groupings exhibit significantly varying MACACC patterns. The methods are described in detail and applied to a normal childhood development population ( n = 292), and show that association cortices have the highest correlation strengths. Taking Brodmann Area (BA) 44 as a seed region revealed MACACC patterns strikingly similar to tractography maps obtained from diffusion tensor imaging. Furthermore, the MACACC map of BA 44 changed with age, older subjects featuring tighter correlations with BA 44 in the anterior portions of the superior temporal gyri. Lastly, IQ-dependent MACACC differences were investigated, revealing steeper correlations between BA 44 and multiple frontal and parietal regions for the higher IQ group, most significantly ( t = 4.0) in the anterior cingulate.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.01.042