Immune response to a killed infectious bursal disease virus vaccine in inbred chicken lines with different major histocompatibility complex haplotypes

The influence of MHC on antibody responses to killed infectious bursal disease virus (IBDV) vaccine was investigated in several MHC inbred chicken lines. We found a notable MHC haplotype effect on the specific antibody response against IBDV as measured by ELISA. Some MHC haplotypes were high respond...

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Bibliographic Details
Published in:Poultry science 2006-06, Vol.85 (6), p.986-998
Main Authors: Juul-Madsen, H.R, Dalgaard, T.S, Rontved, C.M, Jensen, K.H, Bumstead, N
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
antibody formation
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
chickens
Chickens - immunology
Flow Cytometry
Haplotypes
humoral immunity
immunoglobulin G
Immunoglobulin G - blood
immunoglobulin M
Immunoglobulin M - blood
inactivated vaccines
inbred lines
Inbreeding
Infectious bursal disease virus - immunology
Kinetics
Leukocyte Count
Lymphocyte Count
Major Histocompatibility Complex - genetics
Major Histocompatibility Complex - immunology
Viral Vaccines - immunology
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Summary:The influence of MHC on antibody responses to killed infectious bursal disease virus (IBDV) vaccine was investigated in several MHC inbred chicken lines. We found a notable MHC haplotype effect on the specific antibody response against IBDV as measured by ELISA. Some MHC haplotypes were high responders (B201, B4, and BR5), whereas other MHC haplotypes were low responders (B19, B12 and BW3). The humoral response of 1 pair of recombinants isolated from a Red Jungle Fowl (BW3 and BW4) being identical on BF and BG, but different on BL, indicated that part of the primary vaccine response was an MHC II restricted T-cell dependent response. The humoral response in another pair of recombinant haplotypes originating in 2 different White Leghorn chickens being BF21, BL21, BG15 (BR4) and BF15, BL15, BG21 (BR5) on the MHC locus indicated that the BG locus may perform an adjuvant effect on the antibody response as well. Vaccination of chickens at different ages and in lines with different origin indicated that age and background genes also influence the specific antibody response against inactivated IBDV vaccine.
ISSN:0032-5791
1525-3171
DOI:10.1093/ps/85.6.986