Parvovirus B19 Infection Contributes to Severe Anemia in Young Children in Papua New Guinea

BackgroundSevere anemia (hemoglobin level, 90% in 6-year-olds ConclusionsB19 infections play a significant role in the etiology of severe anemia in this area of malarial endemicity. Given the high levels of morbidity and mortality associated with severe anemia in such regions, the prevention of B19...

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Bibliographic Details
Published in:The Journal of infectious diseases 2006-07, Vol.194 (2), p.146-153
Main Authors: Wildig, James, Michon, Pascal, Siba, Peter, Mellombo, Mata, Ura, Alice, Mueller, Ivo, Cossart, Yvonne
Format: Article
Language:English
Subjects:
Aging
Anemia
Anemia - complications
Antibodies, Viral - blood
Blood
Case-Control Studies
Child, Preschool
Children
Erythrocytes
Female
Hemoglobins
Humans
Immunoglobulin M - blood
Infant
Infections
Malaria
Malaria, Falciparum - complications
Male
Odds Ratio
Papua New Guinea
Parvoviridae Infections - complications
Parvoviridae Infections - virology
Parvovirus
Parvovirus B19
Parvovirus B19, Human
Polymerase chain reaction
Specimens
Viruses
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Summary:BackgroundSevere anemia (hemoglobin level, 90% in 6-year-olds ConclusionsB19 infections play a significant role in the etiology of severe anemia in this area of malarial endemicity. Given the high levels of morbidity and mortality associated with severe anemia in such regions, the prevention of B19 infection with a vaccine might be a highly effective public health intervention
ISSN:0022-1899
1537-6613
DOI:10.1086/505082