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Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month
To investigate the effect of short-term high-dose atorvastatin on blood and plaque inflammation in patients with carotid stenosis. Twenty patients undergoing carotid endarterectomy without previous statin treatment were randomized to receive either atorvastatin 80 mg/d (n=11) or no statins (n=9) for...
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| Published in: | Stroke (1970) 2005-08, Vol.36 (8), p.1796-1800 |
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| cites | cdi_FETCH-LOGICAL-c435t-bcabac40d259b60e698d9a7766c4b72fa05e295301a2a9aa0dfd0314d452ebb93 |
| container_end_page | 1800 |
| container_issue | 8 |
| container_start_page | 1796 |
| container_title | Stroke (1970) |
| container_volume | 36 |
| creator | MARTFN-VENTURA, Jose Luis BLANCO-COLIO, Luis Miguel GOMEZ-HERNANDEZ, Almudena MUNOZ-GARCIA, Begona VEGA, Melina SERRANO, Javier ORTEGA, Luis HERNANDEZ, Gonzalo TUNON, José EGIDO, Jesus |
| description | To investigate the effect of short-term high-dose atorvastatin on blood and plaque inflammation in patients with carotid stenosis.
Twenty patients undergoing carotid endarterectomy without previous statin treatment were randomized to receive either atorvastatin 80 mg/d (n=11) or no statins (n=9) for 1 month. We studied inflammatory mediators in plasma (enzyme-linked immunosorbent assay), peripheral blood mononuclear cells (PBMCs; quantitative RT-PCR and EMSA) and plaques (immunohistochemistry and Southwestern histochemistry).
Atorvastatin significantly decreased total and low-density lipoprotein cholesterol and prostaglandin E2 plasma levels. PBMCs from treated patients showed impaired NF-kappaB activation and MCP-1 and COX-2 mRNA expression. Carotid atherosclerotic plaques demonstrated a significant reduction in macrophage infiltration, activated NF-kappaB, and COX-2 and MCP-1 expression.
Intensive treatment with atorvastatin decreases inflammatory activity of PBMCs and carotid atherosclerotic plaques in 1 month. These data strongly suggest that the antiinflammatory effect of high doses of statins in humans can be seen very early. |
| doi_str_mv | 10.1161/01.STR.0000174289.34110.b0 |
| format | article |
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Twenty patients undergoing carotid endarterectomy without previous statin treatment were randomized to receive either atorvastatin 80 mg/d (n=11) or no statins (n=9) for 1 month. We studied inflammatory mediators in plasma (enzyme-linked immunosorbent assay), peripheral blood mononuclear cells (PBMCs; quantitative RT-PCR and EMSA) and plaques (immunohistochemistry and Southwestern histochemistry).
Atorvastatin significantly decreased total and low-density lipoprotein cholesterol and prostaglandin E2 plasma levels. PBMCs from treated patients showed impaired NF-kappaB activation and MCP-1 and COX-2 mRNA expression. Carotid atherosclerotic plaques demonstrated a significant reduction in macrophage infiltration, activated NF-kappaB, and COX-2 and MCP-1 expression.
Intensive treatment with atorvastatin decreases inflammatory activity of PBMCs and carotid atherosclerotic plaques in 1 month. These data strongly suggest that the antiinflammatory effect of high doses of statins in humans can be seen very early.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000174289.34110.b0</identifier><identifier>PMID: 16020773</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Anti-Inflammatory Agents - pharmacology ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - drug therapy ; Atorvastatin Calcium ; Biological and medical sciences ; Blood and lymphatic vessels ; Blotting, Southern ; Blotting, Western ; Cardiology. Vascular system ; Cardiovascular system ; Carotid Arteries - pathology ; Chemokine CCL2 - metabolism ; Cyclooxygenase 2 - metabolism ; Dinoprostone - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Heptanoic Acids - therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Inflammation - drug therapy ; Leukocytes, Mononuclear - cytology ; Leukocytes, Mononuclear - metabolism ; Lipids ; Male ; Medical sciences ; Middle Aged ; Neurology ; NF-kappa B - metabolism ; Pharmacology. Drug treatments ; Pyrroles - therapeutic use ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Vascular diseases and vascular malformations of the nervous system ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>Stroke (1970), 2005-08, Vol.36 (8), p.1796-1800</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-bcabac40d259b60e698d9a7766c4b72fa05e295301a2a9aa0dfd0314d452ebb93</citedby><cites>FETCH-LOGICAL-c435t-bcabac40d259b60e698d9a7766c4b72fa05e295301a2a9aa0dfd0314d452ebb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17008434$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16020773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARTFN-VENTURA, Jose Luis</creatorcontrib><creatorcontrib>BLANCO-COLIO, Luis Miguel</creatorcontrib><creatorcontrib>GOMEZ-HERNANDEZ, Almudena</creatorcontrib><creatorcontrib>MUNOZ-GARCIA, Begona</creatorcontrib><creatorcontrib>VEGA, Melina</creatorcontrib><creatorcontrib>SERRANO, Javier</creatorcontrib><creatorcontrib>ORTEGA, Luis</creatorcontrib><creatorcontrib>HERNANDEZ, Gonzalo</creatorcontrib><creatorcontrib>TUNON, José</creatorcontrib><creatorcontrib>EGIDO, Jesus</creatorcontrib><title>Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>To investigate the effect of short-term high-dose atorvastatin on blood and plaque inflammation in patients with carotid stenosis.
Twenty patients undergoing carotid endarterectomy without previous statin treatment were randomized to receive either atorvastatin 80 mg/d (n=11) or no statins (n=9) for 1 month. We studied inflammatory mediators in plasma (enzyme-linked immunosorbent assay), peripheral blood mononuclear cells (PBMCs; quantitative RT-PCR and EMSA) and plaques (immunohistochemistry and Southwestern histochemistry).
Atorvastatin significantly decreased total and low-density lipoprotein cholesterol and prostaglandin E2 plasma levels. PBMCs from treated patients showed impaired NF-kappaB activation and MCP-1 and COX-2 mRNA expression. Carotid atherosclerotic plaques demonstrated a significant reduction in macrophage infiltration, activated NF-kappaB, and COX-2 and MCP-1 expression.
Intensive treatment with atorvastatin decreases inflammatory activity of PBMCs and carotid atherosclerotic plaques in 1 month. These data strongly suggest that the antiinflammatory effect of high doses of statins in humans can be seen very early.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - drug therapy</subject><subject>Atorvastatin Calcium</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blotting, Southern</subject><subject>Blotting, Western</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Carotid Arteries - pathology</subject><subject>Chemokine CCL2 - metabolism</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Dinoprostone - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Heptanoic Acids - therapeutic use</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Image Processing, Computer-Assisted</subject><subject>Immunohistochemistry</subject><subject>Inflammation - drug therapy</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>NF-kappa B - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrroles - therapeutic use</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpFkFuLFDEQhYMo7rj6FyQI-tZj5dLpjm-yeFlYEHR9DtXpaqalO1mT9C6--NvNuANTL6FS3zlVHMbeCNgLYcR7EPsft9_3UEt0WvZ2r7SowwGesJ1opW60kf1TtgNQtpHa2gv2IudflZeqb5-zC2FAQtepHft7HQqFPN8TL4mwrBQKf5jLgWOJ6R5zwTIHnmjcPGU-h2nBda1_MdSGrzHEsPmFMHFPy5I5hpEfthVDNThQirkOUyyz5wvlqjp68BjoKC2Hl-zZhEumV6f3kv38_On26mtz8-3L9dXHm8Zr1ZZm8Dig1zDK1g4GyNh-tNh1xng9dHJCaEnaVoFAiRYRxmkEJfSoW0nDYNUle_foe5fi741yceucjwdjoLhlZ3roTVVU8MMj6OvpOdHk7tK8YvrjBLhj-g6Eq-m7c_ruf_pugCp-fdqyDSuNZ-kp7gq8PQGYPS5TwuDnfOY6gF4rrf4BdtuR9A</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>MARTFN-VENTURA, Jose Luis</creator><creator>BLANCO-COLIO, Luis Miguel</creator><creator>GOMEZ-HERNANDEZ, Almudena</creator><creator>MUNOZ-GARCIA, Begona</creator><creator>VEGA, Melina</creator><creator>SERRANO, Javier</creator><creator>ORTEGA, Luis</creator><creator>HERNANDEZ, Gonzalo</creator><creator>TUNON, José</creator><creator>EGIDO, Jesus</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month</title><author>MARTFN-VENTURA, Jose Luis ; BLANCO-COLIO, Luis Miguel ; GOMEZ-HERNANDEZ, Almudena ; MUNOZ-GARCIA, Begona ; VEGA, Melina ; SERRANO, Javier ; ORTEGA, Luis ; HERNANDEZ, Gonzalo ; TUNON, José ; EGIDO, Jesus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-bcabac40d259b60e698d9a7766c4b72fa05e295301a2a9aa0dfd0314d452ebb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - drug therapy</topic><topic>Atorvastatin Calcium</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blotting, Southern</topic><topic>Blotting, Western</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Carotid Arteries - pathology</topic><topic>Chemokine CCL2 - metabolism</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Dinoprostone - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Heptanoic Acids - therapeutic use</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Image Processing, Computer-Assisted</topic><topic>Immunohistochemistry</topic><topic>Inflammation - drug therapy</topic><topic>Leukocytes, Mononuclear - cytology</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lipids</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>NF-kappa B - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrroles - therapeutic use</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARTFN-VENTURA, Jose Luis</creatorcontrib><creatorcontrib>BLANCO-COLIO, Luis Miguel</creatorcontrib><creatorcontrib>GOMEZ-HERNANDEZ, Almudena</creatorcontrib><creatorcontrib>MUNOZ-GARCIA, Begona</creatorcontrib><creatorcontrib>VEGA, Melina</creatorcontrib><creatorcontrib>SERRANO, Javier</creatorcontrib><creatorcontrib>ORTEGA, Luis</creatorcontrib><creatorcontrib>HERNANDEZ, Gonzalo</creatorcontrib><creatorcontrib>TUNON, José</creatorcontrib><creatorcontrib>EGIDO, Jesus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARTFN-VENTURA, Jose Luis</au><au>BLANCO-COLIO, Luis Miguel</au><au>GOMEZ-HERNANDEZ, Almudena</au><au>MUNOZ-GARCIA, Begona</au><au>VEGA, Melina</au><au>SERRANO, Javier</au><au>ORTEGA, Luis</au><au>HERNANDEZ, Gonzalo</au><au>TUNON, José</au><au>EGIDO, Jesus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>36</volume><issue>8</issue><spage>1796</spage><epage>1800</epage><pages>1796-1800</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>To investigate the effect of short-term high-dose atorvastatin on blood and plaque inflammation in patients with carotid stenosis.
Twenty patients undergoing carotid endarterectomy without previous statin treatment were randomized to receive either atorvastatin 80 mg/d (n=11) or no statins (n=9) for 1 month. We studied inflammatory mediators in plasma (enzyme-linked immunosorbent assay), peripheral blood mononuclear cells (PBMCs; quantitative RT-PCR and EMSA) and plaques (immunohistochemistry and Southwestern histochemistry).
Atorvastatin significantly decreased total and low-density lipoprotein cholesterol and prostaglandin E2 plasma levels. PBMCs from treated patients showed impaired NF-kappaB activation and MCP-1 and COX-2 mRNA expression. Carotid atherosclerotic plaques demonstrated a significant reduction in macrophage infiltration, activated NF-kappaB, and COX-2 and MCP-1 expression.
Intensive treatment with atorvastatin decreases inflammatory activity of PBMCs and carotid atherosclerotic plaques in 1 month. These data strongly suggest that the antiinflammatory effect of high doses of statins in humans can be seen very early.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16020773</pmid><doi>10.1161/01.STR.0000174289.34110.b0</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 2005-08, Vol.36 (8), p.1796-1800 |
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| subjects | Aged Anti-Inflammatory Agents - pharmacology Atherosclerosis (general aspects, experimental research) Atherosclerosis - drug therapy Atorvastatin Calcium Biological and medical sciences Blood and lymphatic vessels Blotting, Southern Blotting, Western Cardiology. Vascular system Cardiovascular system Carotid Arteries - pathology Chemokine CCL2 - metabolism Cyclooxygenase 2 - metabolism Dinoprostone - blood Enzyme-Linked Immunosorbent Assay Female Heptanoic Acids - therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Image Processing, Computer-Assisted Immunohistochemistry Inflammation - drug therapy Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Lipids Male Medical sciences Middle Aged Neurology NF-kappa B - metabolism Pharmacology. Drug treatments Pyrroles - therapeutic use Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vascular diseases and vascular malformations of the nervous system Vasodilator agents. Cerebral vasodilators |
| title | Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month |
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