IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma

The aim of this study was to determine whether IGF2 polymorphisms are associated with the clearance of hepatitis B virus (HBV) infection and the risk of hepatocellular carcinoma (HCC). A total of 1095 Korean subjects were prospectively enrolled in this case-control study. The rates of IGF2 polymorph...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2006-07, Vol.346 (1), p.38-44
Main Authors: Kim, Yoon Jun, Yoon, Jung-Hwan, Kim, Chung Yong, Kim, Lyoung Hyo, Park, Byung Lae, Shin, Hyoung Doo, Lee, Hyo-Suk
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Asian Continental Ancestry Group - genetics
Association study
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - genetics
Female
Haplotype
Haplotypes
Hepatitis B virus
Hepatitis B virus - immunology
Hepatitis B virus infection
Hepatitis B, Chronic - genetics
Hepatitis B, Chronic - virology
Hepatocellular carcinoma
Humans
IGF2
Insulin-Like Growth Factor II
Korea
Male
Middle Aged
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide
Polymorphisms
Prospective Studies
Proteins - genetics
SNPs
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Summary:The aim of this study was to determine whether IGF2 polymorphisms are associated with the clearance of hepatitis B virus (HBV) infection and the risk of hepatocellular carcinoma (HCC). A total of 1095 Korean subjects were prospectively enrolled in this case-control study. The rates of IGF2 polymorphisms were determined in each group. The IGF2 + 820G allele ( IGF2 + 820G/ G) and the IGF2 + 6815A/ A genotype were strongly associated with the resolution of HBV infection (OR = 0.62–0.73; P = 0.001–0.03 and OR = 0.71; P = 0.03, respectively). Haplotype analysis showed that IGF2-haplotype5 (A-C-C-T-A-T-G) and IGF2-haplotype1 (T-C-T-T-A-C-A) were significantly associated with the clearance and persistence of HBV infection (OR = 0.55–0.58, P = 0.009–0.01 and OR = 1.31–1.65, P = 0.001–0.007, respectively). On the other hand, the IGF2 + 2482C/ C or + 820G/ G genotypes were significantly associated with a higher risk of HCC (OR = 1.88, 1.68; P = 0.04). IGF2 polymorphisms were found to be strongly associated with the clearance of HBV or the occurrence of HCC in patients with chronic HBV infection.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2006.05.080