A simple and fast method for the preparation of n.c.a. 2-[ 18F]F-A85380 for human use

2-[ 18F]F-A85380 is the first subtype selective PET-radiotracer to visualize the distribution of α 4 β 2 nicotinic acetylcholine receptors in human brain in vivo. We investigated a fast and safe automated production of 2-[ 18F]F-A85380 by purification of the BOC-protected intermediate product with a...

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Bibliographic Details
Published in:Applied radiation and isotopes 2005-10, Vol.63 (4), p.433-435
Main Authors: Schmaljohann, J., Gündisch, D., Minnerop, M., Joe, A., Bucerius, J., Dittmar, C., Jessen, F., Guhlke, S., Wüllner, U.
Format: Article
Language:English
Subjects:
2- 18F-A85380
Azetidines - chemical synthesis
Brain - diagnostic imaging
Brain - metabolism
Fluor-18
Humans
Hydrogen-Ion Concentration
Nicotinic acetylcholine receptor
PET
Positron-Emission Tomography
Pyridines - chemical synthesis
Radiopharmaceuticals - chemical synthesis
Receptors, Nicotinic - metabolism
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Summary:2-[ 18F]F-A85380 is the first subtype selective PET-radiotracer to visualize the distribution of α 4 β 2 nicotinic acetylcholine receptors in human brain in vivo. We investigated a fast and safe automated production of 2-[ 18F]F-A85380 by purification of the BOC-protected intermediate product with a combination of solid phase extraction cartridges. After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[ 18F]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55% in 35 minutes.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2005.05.040