Relation of Brachial Artery Reactivity to Nitroglycerin and Heart Rate Recovery Following Exercise in Healthy Male Volunteers

The parasympathetic nervous system facilitates peripheral arterial vasodilation and is also responsible for a decrease in heart rate immediately after exercise (heart rate recovery [HRR]). The relation among parasympathetic tone measured by HRR after exercise, endothelium-mediated vasodilation, and...

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Bibliographic Details
Published in:The American journal of cardiology 2005-08, Vol.96 (3), p.447-449
Main Authors: Girod, John P., Garcia, Mario J., Saunders, Sue, Drinko, Jeanne, Brotman, Daniel J.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Flow Velocity
Brachial Artery - diagnostic imaging
Brachial Artery - drug effects
Brachial Artery - physiology
Cardiology. Vascular system
Drugs
Exercise
Exercise Test
Health
Heart
Heart Rate - drug effects
Heart Rate - physiology
Humans
Lungs
Male
Medical sciences
Men
Nitroglycerin - pharmacology
Pulmonary arteries
Ultrasonography, Doppler
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents - pharmacology
Volunteers
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Summary:The parasympathetic nervous system facilitates peripheral arterial vasodilation and is also responsible for a decrease in heart rate immediately after exercise (heart rate recovery [HRR]). The relation among parasympathetic tone measured by HRR after exercise, endothelium-mediated vasodilation, and nitroglycerin-mediated vasodilation (determined with brachial artery ultrasound) was assessed in 25 healthy young men. One-minute HRR was nonsignificantly related to endothelium-mediated vasodilation (r = −0.35, p = 0.08) but was significantly related to nitroglycerin-mediated vasodilation (r = −0.63, p = 0.0008), a finding that persisted after adjustment for heart rate at rest, insulin resistance, lipid variables, and blood pressure. This suggests that parasympathetic tone may be inversely related to the responsiveness of arterial smooth muscle to nitrates in healthy humans.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.03.098