Magnetic resonance imaging of tumor cells by targeting the amino acid transport system

With the aim of discovering an early diagnosis of cancer by magnetic resonance imaging (MRI), we synthesized and studied six DTPA and DOTA-like gadolinium complexes conjugated to agmatine, arginine, and glutamine (e.g., 7a), able to target tumor cells by means of the glutamine transport system. An e...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2006-08, Vol.16 (15), p.4111-4114
Main Authors: Lattuada, Luciano, Demattio, Silvia, Vincenzi, Veronica, Cabella, Claudia, Visigalli, Massimo, Aime, Silvio, Crich, Simonetta Geninatti, Gianolio, Eliana
Format: Article
Language:English
Subjects:
Amino Acid Transport Systems - metabolism
Amino acid transporters
Animals
Biological and medical sciences
Cell Line, Tumor
Contrast media. Radiopharmaceuticals
Gadolinium
Gadolinium complexes
Glutamine uptake
Investigative techniques, diagnostic techniques (general aspects)
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical sciences
Miscellaneous. Technology
Pharmacology. Drug treatments
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Rats
Tumor cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:With the aim of discovering an early diagnosis of cancer by magnetic resonance imaging (MRI), we synthesized and studied six DTPA and DOTA-like gadolinium complexes conjugated to agmatine, arginine, and glutamine (e.g., 7a), able to target tumor cells by means of the glutamine transport system. An early diagnosis of cancer is crucial in the battle against this disease and the in vivo visualization of tumors at cellular level is still the most challenging goal. In order to target tumor cells, we took into account their increased metabolism and amino acid nutrients or pseudo-nutrients, which are actively transported through the cell membrane, have been chosen as vectors for new MRI contrast agents. For this reason new gadolinium complexes conjugated to agmatine, arginine, and glutamine have been synthesized and studied.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.04.081