Combined effects of iontophoretic and chemical enhancement on drug delivery II. Transport across human and murine skin

This paper reports measurements of the release characteristics of the model drug salbutamol from a liquid crystalline vehicle across both human and hairless murine skin in vitro. The use of oleic acid and iontophoresis as penetration enhancement techniques, used separately and simultaneously, was al...

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Bibliographic Details
Published in:International journal of pharmaceutics 2007-08, Vol.341 (1-2), p.114-124
Main Authors: NOLAN, L. M. A, CORISH, J, CORRIGAN, O. I, FITZPATRICK, D
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Albuterol - metabolism
Animals
Biological and medical sciences
Chemistry, Pharmaceutical
Diclofenac - metabolism
Diffusion
Diffusion Chambers, Culture
Diltiazem - metabolism
Drug Compounding
Drug Delivery Systems - methods
Fatty Acids - administration & dosage
Fatty Acids - chemistry
Fatty Acids - pharmacology
Gels
General pharmacology
Humans
Iontophoresis
Kinetics
Lauric Acids - pharmacology
Liquid Crystals
Medical sciences
Mice
Mice, Hairless
Models, Biological
Nicotine - metabolism
Oleic Acid - pharmacology
Permeability
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Pharmaceutical technology. Pharmaceutical industry
Pharmaceutical Vehicles - chemistry
Pharmacology. Drug treatments
Skin - drug effects
Skin - metabolism
Skin Absorption - drug effects
Stearic Acids - pharmacology
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Summary:This paper reports measurements of the release characteristics of the model drug salbutamol from a liquid crystalline vehicle across both human and hairless murine skin in vitro. The use of oleic acid and iontophoresis as penetration enhancement techniques, used separately and simultaneously, was also investigated. Over a period of 12h, salbutamol base did not diffuse from the vehicle across excised human skin while, in contrast, over a period of 2h, the drug passively transported across hairless murine skin. The diffusion co-efficient for the drug in this tissue was estimated to be 4.54+/-0.60x10(-9)cm(2)s(-1) with a permeability co-efficient of 7.03+/-0.83x10(-7)cms(-1). A current of density of 0.39mAcm(-2) facilitated a significant transport of salbutamol from the liquid crystalline vehicle across excised human skin but with a small (
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2007.04.004