Dynamic survivin in head and neck cancer: Molecular mechanism and therapeutic potential

Although disease management of head and neck squamous cell carcinomas (HNSCC) has improved significantly, therapy resistance leading to tumor recurrence still counteracts improvement of long‐term survival. Consequently, identification of molecular markers that signal increased risk of treatment fail...

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Bibliographic Details
Published in:International journal of cancer 2007-09, Vol.121 (6), p.1169-1174
Main Authors: Lippert, Burkhard M., Knauer, Shirley K., Fetz, Verena, Mann, Wolf, Stauber, Roland H.
Format: Article
Language:English
Subjects:
Animals
apoptosis
Biological and medical sciences
Biomarkers, Tumor
cell cycle
chromosomal passenger complex
CPC
Crm1
head and neck cancer
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - therapy
Humans
Inhibitor of Apoptosis Proteins
LMB
Medical sciences
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - metabolism
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
nucleo‐cytoplasmic transport
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Prognosis
Tumors
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Summary:Although disease management of head and neck squamous cell carcinomas (HNSCC) has improved significantly, therapy resistance leading to tumor recurrence still counteracts improvement of long‐term survival. Consequently, identification of molecular markers that signal increased risk of treatment failure or, which can be exploited by targeted therapy, is urgently needed. Survivin is strongly expressed in HNSCC, and its proposed dual role as an apoptosis inhibitor and a mitotic effector positioned survivin in the front line of cancer research. Notably, survivin is detected as a cytoplasmic and as a nuclear protein in HNSCC patients, which stimulated numerous studies to investigate and to speculate on the functional and prognostic significance of its dynamic localization. This review focuses on our current understanding of the molecular mechanisms regulating survivin's intracellular localization and discusses its potential prognostic and therapeutic relevance for head and neck cancer. © 2007 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.22941