Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery

The aim of the present work is to examine the viability of using large hollow nanoparticulate aggregates as the therapeutic carrier particles in dry powder inhaler delivery of nanoparticulate drugs. The large hollow carrier particles are manufactured by spray drying of nanoparticulate suspensions of...

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Bibliographic Details
Published in:International journal of pharmaceutics 2007-08, Vol.341 (1), p.195-206
Main Authors: Hadinoto, Kunn, Zhu, Kewu, Tan, Reginald B.H.
Format: Article
Language:English
Subjects:
Acrylates - chemistry
Administration, Inhalation
Albuterol - chemistry
Aspirin - chemistry
Biological and medical sciences
Chemistry, Pharmaceutical
Drug Carriers
Drug Compounding
Drug release
Dry powder inhaler
Formulation
General pharmacology
Hollow particles
Kinetics
Medical sciences
Models, Chemical
Nanoparticles
Nanoparticulate drugs
Nebulizers and Vaporizers
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phospholipids - chemistry
Porosity
Powders
Pulmonary delivery
Respiratory System Agents - administration & dosage
Respiratory System Agents - chemistry
Solubility
Surface Properties
Technology, Pharmaceutical
Water - chemistry
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Summary:The aim of the present work is to examine the viability of using large hollow nanoparticulate aggregates as the therapeutic carrier particles in dry powder inhaler delivery of nanoparticulate drugs. The large hollow carrier particles are manufactured by spray drying of nanoparticulate suspensions of biocompatible acrylic polymer with loaded drugs. The size and concentration of the nanoparticles, as well as the phospholipids inclusion, have been known to influence the resulting morphology (i.e. size and degree of hollowness) of the spray-dried carrier particles. The effects of the resulting morphology of the carrier particles on the drug release rate are therefore investigated by varying the above three variables. The results of the drug release study are presented using aspirin and salbutamol sulfate as the model drugs with a varying degree of water solubility. The results indicate that the drug release rate is governed by the degree of hollowness of the carrier particles, and to a lesser extent by the nanoparticles size, as a result of the variation in the drug loading capacity of nanoparticles of different sizes.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2007.03.035