Unnoticed Spread of Class 1 Integrons in Gram-Positive Clinical Strains Isolated in Guangzhou, China

A total of 46 gram‐positive bacteria isolated from clinical specimens collected in China were subjected to PCR analysis with the intI1‐specific primers, and the intI1‐positive strains were further analyzed for their resistance gene cassette. All isolates possessed the class 1 integron in their genom...

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Bibliographic Details
Published in:Microbiology and immunology 2006-01, Vol.50 (6), p.463-467
Main Authors: Shi, Lei, Zheng, Meiping, Xiao, Zenghuang, Asakura, Masahiro, Su, Jianyu, Li, Lin, Yamasaki, Shinji
Format: Article
Language:English
Subjects:
Drug Resistance, Bacterial - genetics
gene cassettes
Gene Transfer, Horizontal
gram-positive bacteria
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - genetics
Humans
Integrons
Microbial Sensitivity Tests
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Summary:A total of 46 gram‐positive bacteria isolated from clinical specimens collected in China were subjected to PCR analysis with the intI1‐specific primers, and the intI1‐positive strains were further analyzed for their resistance gene cassette. All isolates possessed the class 1 integron in their genomes and the array of gene cassettes was dhfrXII‐orfF‐aadA2, which is very similar to other organisms except in one isolate carrying an additional copy of the class 1 integron containing the aadA2 gene cassette. Altogether, the results indicate that the class 1 integron is widespread in gram‐positive clinical strains isolated in Guangzhou, China.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2006.tb03815.x