β-Lactotensin, a neurotensin agonist peptide derived from bovine β-lactoglobulin, enhances memory consolidation in mice

β-Lactotensin (His-Ile-Arg-Leu) is an ileum-contracting tetrapeptide isolated from bovine β-lactoglobulin. We previously reported that a neurotensin agonist β-lactotensin shows antinociceptive effect through neurotensin NT 2 receptor. We found that centrally or orally administered β-lactotensin at a...

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Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2007-07, Vol.28 (7), p.1470-1474
Main Authors: Ohinata, Kousaku, Sonoda, Soushi, Inoue, Natsumi, Yamauchi, Rena, Wada, Keiji, Yoshikawa, Masaaki
Format: Article
Language:English
Subjects:
Animals
Cattle
Lactoglobulins - chemistry
Male
Memory - drug effects
Mice
Mice, Inbred Strains
Oligopeptides - administration & dosage
Oligopeptides - pharmacology
Receptors, Dopamine D2 - metabolism
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cites cdi_FETCH-LOGICAL-c366t-4ecf2920cab968a844d4116bca11f84c49a1f451fd6b3c5518039197e1d387173
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container_issue 7
container_start_page 1470
container_title Peptides (New York, N.Y. : 1980)
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creator Ohinata, Kousaku
Sonoda, Soushi
Inoue, Natsumi
Yamauchi, Rena
Wada, Keiji
Yoshikawa, Masaaki
description β-Lactotensin (His-Ile-Arg-Leu) is an ileum-contracting tetrapeptide isolated from bovine β-lactoglobulin. We previously reported that a neurotensin agonist β-lactotensin shows antinociceptive effect through neurotensin NT 2 receptor. We found that centrally or orally administered β-lactotensin at a dose of 60 nmol/mouse or 300–500 mg/kg, respectively, increased memory consolidation in the step-through-type inhibitory avoidance test in mice. The memory-enhancing activity of β-lactotensin was inhibited by the dopamine D 2 receptor antagonist raclopride but not the D 1 receptor antagonist SCH23390. Taken together, β-lactotensin might improve memory consolidation through activating the dopamine D 2 receptor.
doi_str_mv 10.1016/j.peptides.2007.06.002
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ispartof Peptides (New York, N.Y. : 1980), 2007-07, Vol.28 (7), p.1470-1474
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source ScienceDirect Freedom Collection
subjects Animals
Cattle
Lactoglobulins - chemistry
Male
Memory - drug effects
Mice
Mice, Inbred Strains
Oligopeptides - administration & dosage
Oligopeptides - pharmacology
Receptors, Dopamine D2 - metabolism
title β-Lactotensin, a neurotensin agonist peptide derived from bovine β-lactoglobulin, enhances memory consolidation in mice
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