Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives

A new series of thiazolyl thiazolidine-2,4-diones were synthesized and tested for their in vitro antimicrobial activities. In this study, a series of thiazolyl thiazolidine-2,4-dione derivatives ( Va– f and VIa– f) were synthesized and evaluated for their antibacterial and antifungal activities agai...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2007-09, Vol.15 (18), p.6012-6017
Main Authors: Bozdağ-Dündar, Oya, Özgen, Özen, Menteşe, Arzu, Altanlar, Nurten, Atlı, Onur, Kendi, Engin, Ertan, Rahmiye
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial activity
Biological and medical sciences
Candida albicans - drug effects
Candida albicans - growth & development
Escherichia coli - drug effects
Escherichia coli - growth & development
Medical sciences
Methicillin - pharmacology
Methicillin Resistance
Microbial Sensitivity Tests
Models, Chemical
Molecular Structure
Pharmacology. Drug treatments
Single-X-ray structure
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Thiazole derivatives
Thiazolidine-2,4-diones
Thiazolidines - chemical synthesis
Thiazolidines - chemistry
Thiazolidines - pharmacology
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Summary:A new series of thiazolyl thiazolidine-2,4-diones were synthesized and tested for their in vitro antimicrobial activities. In this study, a series of thiazolyl thiazolidine-2,4-dione derivatives ( Va– f and VIa– f) were synthesized and evaluated for their antibacterial and antifungal activities against Staphylococcus aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), methicillin resistant S. aureus (MRSA isolate), and Escherichia coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used microorganisms.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2007.06.049