GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma

Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associa...

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Bibliographic Details
Published in:Movement disorders 2007-07, Vol.22 (9), p.1343-1346
Main Authors: McHugh, John C., Murray, Brian, Renganathan, Radhakrishnan, Connolly, Sean, Lynch, Tim
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma - complications
Development. Senescence. Regeneration. Transplantation
Electromyography - methods
Fundamental and applied biological sciences. Psychology
GAD
Glutamate Decarboxylase - metabolism
Humans
IVIG
Kidney Neoplasms - complications
Male
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Muscle, Skeletal - physiopathology
Neurology
paraneoplastic
Paraneoplastic Syndromes - etiology
Paraneoplastic Syndromes - metabolism
stiff person syndrome
Vertebrates: nervous system and sense organs
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Summary:Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti‐GAD positive PSPS in a 53‐year‐old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS. © 2007 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.21374