Burden of paediatric rotavirus gastroenteritis and potential benefits of a universal rotavirus vaccination programme with RotaTeq® in France

• Published in: Vaccine 2007-08, Vol.25 (34), p.6348-6358
• Main Authors: Huet, Frédéric, Largeron, Nathalie, Trichard, Mélanie, Miadi-Fargier, Houda, Jasso-Mosqueda, Guillermo
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Biological and medical sciences; Burden of disease; Child, Preschool; Children & youth; Cost of Illness; Diarrhea; Discount rates; France - epidemiology; Fundamental and applied biological sciences. Psychology; Gastroenteritis; Gastroenteritis - economics; Gastroenteritis - epidemiology; Gastroenteritis - prevention & control; Health care; Humans; Immunization; Infant; Infant, Newborn; Microbiology; Miscellaneous; Nosocomial infection; Nosocomial infections; Paediatric gastroenteritis; Rotavirus; Rotavirus Infections - economics; Rotavirus Infections - epidemiology; Rotavirus Infections - prevention & control; Rotavirus Vaccines - immunology; Vaccination; Vaccines; Virology
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2007.06.015

Abstract This study aimed at estimating the paediatric RotaVirus GastroEnteritis (RVGE) burden in children aged up to 5 years, and at evaluating health and economic benefits of a universal infant vaccination with a pentavalent rotavirus vaccine, in France. A decision analytic model was constructed considering a cohort of French children from birth to 5 years old. In the absence of a universal rotavirus immunisation programme, the model predicts that of every new French birth cohort, 336,738 children would present a RVGE case, which would result in 33,386 hospitalisations, 14 deaths and more than 279,000 work days lost for the parents. The management of these RVGE cases would cost €63 million to the National Healthcare Payer and would reach up to €117 million when all indirect costs were included. The introduction of a universal rotavirus vaccination would avoid 249,400 RVGE cases and consequently about 25,700 hospitalisations, 6000 nosocomial infections, 81,200 emergency visits, 39,900 general practitioner or paediatrician consultations, 11 deaths and 206,700 parental work days lost. RVGE total costs would be reduced by €47 million for the National Healthcare Payer and by €88 million from the Societal perspective. Therefore, a routine universal rotavirus vaccination programme represents an opportunity to significantly reduce the high paediatric RVGE burden in France.