Cenp-F (mitosin) is more than a mitotic marker

Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recen...

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Bibliographic Details
Published in:Chromosoma 2006-08, Vol.115 (4), p.288-295
Main Authors: Varis, Asta, Salmela, Anna-Leena, Kallio, Marko J
Format: Article
Language:English
Subjects:
Alkyl and Aryl Transferases - metabolism
Animals
Biomarkers - metabolism
Cell division
Cell Proliferation
Chromosomal Proteins, Non-Histone - genetics
Chromosomal Proteins, Non-Histone - metabolism
Chromosomal Proteins, Non-Histone - physiology
Humans
Kinetochores - metabolism
Microfilament Proteins - genetics
Microfilament Proteins - metabolism
Microfilament Proteins - physiology
Mitosis
Models, Genetic
Protein Prenylation
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Summary:Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein's post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.
ISSN:0009-5915
1432-0886
DOI:10.1007/s00412-005-0046-0