Biosynthesis of Streptolydigin:  Origin of the Oxygen Atoms

Biosynthetic incorporations of [13C,18O]-labeled precursors into streptolydigin reveal the origin of the oxygen atoms, limiting the possible pathways for acyltetramic acid ring assembly and for formation of the bicyclic ketal.

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Bibliographic Details
Published in:Organic letters 2006-11, Vol.8 (23), p.5329-5332
Main Authors: Chen, Hao, Olesen, Solveig G, Harrison
Format: Article
Language:English
Subjects:
Aminoglycosides - biosynthesis
Aminoglycosides - chemistry
Molecular Structure
Oxygen - chemistry
Oxygen - metabolism
Oxygen Isotopes
Streptomyces - metabolism
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Description
Summary:Biosynthetic incorporations of [13C,18O]-labeled precursors into streptolydigin reveal the origin of the oxygen atoms, limiting the possible pathways for acyltetramic acid ring assembly and for formation of the bicyclic ketal.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0621304