Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice

Anatomical and functional studies support segregation of the hippocampus into ventral and dorsal components along its septotemporal axis. However, it is unknown whether the development of these two components of the hippocampus is influenced by common or separate genetic factors. In this study, we u...

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Bibliographic Details
Published in:Genes, brain and behavior brain and behavior, 2006-11, Vol.5 (8), p.614-623
Main Authors: Martin, Maureen V., Dong, Hongxin, Vallera, Dana, Lee, David, Lu, Lu, Williams, Robert W., Rosen, Glenn D., Cheverud, James M., Csernansky, John G.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Anterior hippocampus
AXB
BXA
BXD
Chromosome Mapping
dorsal hippocampus
Female
Hippocampus - anatomy & histology
Hippocampus - growth & development
Male
Mice
Mice, Inbred Strains
Organ Size - genetics
Phenotype
posterior hippocampus
Quantitative Trait Loci - genetics
quantitative trait locus
recombinant inbred strains
Recombination, Genetic
schizophrenia
Sex Factors
Species Specificity
ventral hippocampus
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Summary:Anatomical and functional studies support segregation of the hippocampus into ventral and dorsal components along its septotemporal axis. However, it is unknown whether the development of these two components of the hippocampus is influenced by common or separate genetic factors. In this study, we used recombinant inbred strains of mice to determine whether the same or different quantitative trait loci (QTL) influence ventral and dorsal hippocampal volume. Using two sets of strains of recombinant inbred mice (BXD and AXB/BXA), we identified separate QTLs for ventral and dorsal hippocampal volume. In BXD mice, suggestive QTLs for ventral hippocampus were identified on chromosomes 2, 8 and 13, and a significant QTL for dorsal hippocampal volume was identified on chromosome 15. There was also a suggestive QTL for dorsal hippocampal volume on chromosome 13. In AXB/BXA mice, there were no significant or suggestive QTLs for ventral hippocampal volume, but a significant QTL for dorsal hippocampus was identified on chromosome 5. These findings suggest that the development of the ventral and dorsal components of the hippocampus is influenced by separate genetic loci.
ISSN:1601-1848
1601-183X
DOI:10.1111/j.1601-183X.2006.00215.x