Efficacy of Tokishakuyakusan on the Anemia in the Iron-Deficient Pregnant Rats

Iron-deficiency anemia not only causes insufficient oxygen delivery to the body of the mother, but creates serious conditions in the fetus, such as insufficient oxygen delivery and poor development, and its treatment has become an important issue. To elucidate the mechanism of the anemia-amelioratin...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2007/08/01, Vol.30(8), pp.1523-1528
Main Authors: Akase, Tomoko, Hihara, Emiko, Shimada, Tsutomu, Kojima, Kazuko, Akase, Tomohide, Tashiro, Shin-ichi, Aburada, Masaki
Format: Article
Language:English
Subjects:
Anemia, Hypochromic - drug therapy
Animals
Bone Marrow Cells - drug effects
Bone Marrow Cells - ultrastructure
Drugs, Chinese Herbal - therapeutic use
Erythrocytes - drug effects
Erythrocytes - ultrastructure
Erythropoietin - metabolism
Female
Hematocrit
Hemoglobins - metabolism
iron-deficiency anemia
Pregnancy
Pregnancy, Animal - metabolism
rat
Rats
Rats, Wistar
Tokishakuyakusan
Transferrin - metabolism
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Summary:Iron-deficiency anemia not only causes insufficient oxygen delivery to the body of the mother, but creates serious conditions in the fetus, such as insufficient oxygen delivery and poor development, and its treatment has become an important issue. To elucidate the mechanism of the anemia-ameliorating action of Tokishakuyakusan, we investigated the effect of administration of Tokishakuyakusan on anemia-related parameters and the serum transferrin and erythropoietin levels, erythrocyte morphology, and bone marrow cells in pregnant rats and in pregnant rats with iron-deficiency anemia. The results showed that Tokishakuyakusan significantly improved the low erythrocyte count, hemoglobin, and hematocrit values of the pregnant rats in the iron-deficient state, increased the proportion of normal erythrocytes in terms of erythrocyte morphology, increased the proportion of erythroblasts among bone marrow cells, and also significantly increased the erythropoietin and transferrin levels in the blood. These findings suggested that Tokishakuyakusan promotes erythrocyte differentiation in iron-deficiency anemia, and that it possesses anemia-ameliorating efficacy.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.30.1523