Possible mechanisms of neurodegeneration in schizophrenia

Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patien...

Full description

Saved in:
Bibliographic Details
Published in:Neurochemical research 2006-10, Vol.31 (10), p.1279-1294
Main Authors: Pérez-Neri, Iván, Ramírez-Bermúdez, Jesús, Montes, Sergio, Ríos, Camilo
Format: Article
Language:English
Subjects:
Antipsychotic Agents - therapeutic use
Brain - abnormalities
Dopamine - physiology
Glutamic Acid - physiology
Humans
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - physiopathology
Nitric Oxide - biosynthesis
Schizophrenia - drug therapy
Schizophrenia - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c423t-c0ce38739519a6ea72f573438196a38a50d7a9eb63133e5823078396c552a99b3
cites cdi_FETCH-LOGICAL-c423t-c0ce38739519a6ea72f573438196a38a50d7a9eb63133e5823078396c552a99b3
container_end_page 1294
container_issue 10
container_start_page 1279
container_title Neurochemical research
container_volume 31
creator Pérez-Neri, Iván
Ramírez-Bermúdez, Jesús
Montes, Sergio
Ríos, Camilo
description Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.
doi_str_mv 10.1007/s11064-006-9162-3
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68112766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20456335</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-c0ce38739519a6ea72f573438196a38a50d7a9eb63133e5823078396c552a99b3</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EoqXwA1hQxMAWuPPVdjwixJdUCQaYLSe90FRNUuxmgF-Pq1ZCYmG64Z73Ph4hzhGuEcDcRETQ0xxA5xa1zOlAjFEZyrUFOhRjoNQltDASJzEuAVJK4rEYoUkZo4qxsK99jE254qzlauG7JrYx6-us4yH0c_7gjoPfNH2XNV0Wq0Xz3a8XgbvGn4qj2q8in-3rRLw_3L_dPeWzl8fnu9tZXk0lbfIKKqbCkFVovWZvZJ0unFKBVnsqvIK58ZZLTUjEqpAEpiCrK6Wkt7akibjazV2H_nPguHFtEyterXzH_RCdLhCl0fpfUMJUaSKVwMs_4LIfQpeecFJi2g5oEoQ7qArJUODarUPT-vDlENzWvtvZd8mk29p3lDIX-8FD2fL8N7HXTT8weH1t</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221783017</pqid></control><display><type>article</type><title>Possible mechanisms of neurodegeneration in schizophrenia</title><source>Springer Link</source><creator>Pérez-Neri, Iván ; Ramírez-Bermúdez, Jesús ; Montes, Sergio ; Ríos, Camilo</creator><creatorcontrib>Pérez-Neri, Iván ; Ramírez-Bermúdez, Jesús ; Montes, Sergio ; Ríos, Camilo</creatorcontrib><description>Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-006-9162-3</identifier><identifier>PMID: 17006758</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Antipsychotic Agents - therapeutic use ; Brain - abnormalities ; Dopamine - physiology ; Glutamic Acid - physiology ; Humans ; Neurodegenerative Diseases - drug therapy ; Neurodegenerative Diseases - physiopathology ; Nitric Oxide - biosynthesis ; Schizophrenia - drug therapy ; Schizophrenia - physiopathology</subject><ispartof>Neurochemical research, 2006-10, Vol.31 (10), p.1279-1294</ispartof><rights>Springer Science+Business Media, LLC 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-c0ce38739519a6ea72f573438196a38a50d7a9eb63133e5823078396c552a99b3</citedby><cites>FETCH-LOGICAL-c423t-c0ce38739519a6ea72f573438196a38a50d7a9eb63133e5823078396c552a99b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17006758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez-Neri, Iván</creatorcontrib><creatorcontrib>Ramírez-Bermúdez, Jesús</creatorcontrib><creatorcontrib>Montes, Sergio</creatorcontrib><creatorcontrib>Ríos, Camilo</creatorcontrib><title>Possible mechanisms of neurodegeneration in schizophrenia</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.</description><subject>Antipsychotic Agents - therapeutic use</subject><subject>Brain - abnormalities</subject><subject>Dopamine - physiology</subject><subject>Glutamic Acid - physiology</subject><subject>Humans</subject><subject>Neurodegenerative Diseases - drug therapy</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - physiopathology</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EoqXwA1hQxMAWuPPVdjwixJdUCQaYLSe90FRNUuxmgF-Pq1ZCYmG64Z73Ph4hzhGuEcDcRETQ0xxA5xa1zOlAjFEZyrUFOhRjoNQltDASJzEuAVJK4rEYoUkZo4qxsK99jE254qzlauG7JrYx6-us4yH0c_7gjoPfNH2XNV0Wq0Xz3a8XgbvGn4qj2q8in-3rRLw_3L_dPeWzl8fnu9tZXk0lbfIKKqbCkFVovWZvZJ0unFKBVnsqvIK58ZZLTUjEqpAEpiCrK6Wkt7akibjazV2H_nPguHFtEyterXzH_RCdLhCl0fpfUMJUaSKVwMs_4LIfQpeecFJi2g5oEoQ7qArJUODarUPT-vDlENzWvtvZd8mk29p3lDIX-8FD2fL8N7HXTT8weH1t</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Pérez-Neri, Iván</creator><creator>Ramírez-Bermúdez, Jesús</creator><creator>Montes, Sergio</creator><creator>Ríos, Camilo</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Possible mechanisms of neurodegeneration in schizophrenia</title><author>Pérez-Neri, Iván ; Ramírez-Bermúdez, Jesús ; Montes, Sergio ; Ríos, Camilo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-c0ce38739519a6ea72f573438196a38a50d7a9eb63133e5823078396c552a99b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antipsychotic Agents - therapeutic use</topic><topic>Brain - abnormalities</topic><topic>Dopamine - physiology</topic><topic>Glutamic Acid - physiology</topic><topic>Humans</topic><topic>Neurodegenerative Diseases - drug therapy</topic><topic>Neurodegenerative Diseases - physiopathology</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez-Neri, Iván</creatorcontrib><creatorcontrib>Ramírez-Bermúdez, Jesús</creatorcontrib><creatorcontrib>Montes, Sergio</creatorcontrib><creatorcontrib>Ríos, Camilo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez-Neri, Iván</au><au>Ramírez-Bermúdez, Jesús</au><au>Montes, Sergio</au><au>Ríos, Camilo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible mechanisms of neurodegeneration in schizophrenia</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>31</volume><issue>10</issue><spage>1279</spage><epage>1294</epage><pages>1279-1294</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>17006758</pmid><doi>10.1007/s11064-006-9162-3</doi><tpages>16</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0364-3190
ispartof Neurochemical research, 2006-10, Vol.31 (10), p.1279-1294
issn 0364-3190
1573-6903
language eng
recordid cdi_proquest_miscellaneous_68112766
source Springer Link
subjects Antipsychotic Agents - therapeutic use
Brain - abnormalities
Dopamine - physiology
Glutamic Acid - physiology
Humans
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - physiopathology
Nitric Oxide - biosynthesis
Schizophrenia - drug therapy
Schizophrenia - physiopathology
title Possible mechanisms of neurodegeneration in schizophrenia
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T13%3A01%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Possible%20mechanisms%20of%20neurodegeneration%20in%20schizophrenia&rft.jtitle=Neurochemical%20research&rft.au=P%C3%A9rez-Neri,%20Iv%C3%A1n&rft.date=2006-10-01&rft.volume=31&rft.issue=10&rft.spage=1279&rft.epage=1294&rft.pages=1279-1294&rft.issn=0364-3190&rft.eissn=1573-6903&rft_id=info:doi/10.1007/s11064-006-9162-3&rft_dat=%3Cproquest_cross%3E20456335%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c423t-c0ce38739519a6ea72f573438196a38a50d7a9eb63133e5823078396c552a99b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=221783017&rft_id=info:pmid/17006758&rfr_iscdi=true