Membrane-Bound Water is Energetically Decoupled from Nearby Bulk Water:  An Ultrafast Surface-Specific Investigation

We report a femtosecond time-resolved study of ultrafast vibrational dynamics of membrane-bound water. The O−H stretch vibrational lifetime of water bound to a phosphatidylserine lipid monolayer is measured by employing a pump−probe scheme and using vibrational sum frequency generation (VSFG) as a s...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2007-08, Vol.129 (31), p.9608-9609
Main Authors: Ghosh, Avishek, Smits, Marc, Bredenbeck, Jens, Bonn, Mischa
Format: Article
Language:English
Subjects:
Spectrophotometry
Surface Properties
Time Factors
Water - chemistry
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Summary:We report a femtosecond time-resolved study of ultrafast vibrational dynamics of membrane-bound water. The O−H stretch vibrational lifetime of water bound to a phosphatidylserine lipid monolayer is measured by employing a pump−probe scheme and using vibrational sum frequency generation (VSFG) as a surface-specific probe. We conclusively demonstrate that water molecules adjacent to a lipid layer are energetically decoupled from the bulk and therefore constitute an intrinsic part of the membrane. This contrasts starkly with recent observations by us and other groups that other types of interfacial water exchange energy efficiently with the underlying bulk.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja073130h