The relationship between variables of 123-I-metaiodobenzylguanidine cardiac imaging and clinical status of the patients with diastolic heart failure

• Published in: International journal of cardiology 2006-11, Vol.113 (2), p.223-228
• Main Authors: Sugiura, Masato, Yamamoto, Koji, Takeda, Yutaka, Takeda, Yasuko, Dohmori, Takemasa, Ogata, Masaki, Kondo, Hiroaki, Suzuki, Shogo, Fukutomi, Tatsuya
• Format: Article
• Language: English
• Subjects: 3-Iodobenzylguanidine; Aged; Biological and medical sciences; Cardiac sympathetic nerve; Cardiology. Vascular system; Diastole; Echocardiography, Doppler, Pulsed; Female; Follow-Up Studies; Gated Blood-Pool Imaging - methods; Heart; Heart Failure - diagnostic imaging; Heart Failure - physiopathology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Male; Medical sciences; Myocardial Contraction - physiology; Neurohumoral factors; Prognosis; Radiopharmaceuticals; Scintigraphy; Severity of Illness Index; Stroke Volume - physiology; Ventricular Function, Left - physiology
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2005.11.017

The status of cardiac sympathetic nerve activity in patients with diastolic heart failure has not been fully understood. 123-I-metaiodobenzylguanidine cardiac images are valuable for evaluating cardiac sympathetic nerve activity. We obtained 123-I-metaiodobenzylguanidine cardiac images from 34 consecutive patients with moderate heart failure and an ejection fraction of ≥ 45%. The decay-corrected washout rate of 123-I-metaiodobenzylguanidine correlated with each plasma concentration of brain natriuretic peptide (standardized correlation coefficient = 0.305, p < 0.05), New York Heart Association functional class (standardized correlation coefficient = 0.364, p < 0.02), and exercise capacity (standardized correlation coefficient = − 0.388, p < 0.04). A multiple regression analysis revealed that the washout rate independently predicted plasma concentration of brain natriuretic peptide (standardized regression coefficient = 0.367, p < 0.02). In a univariate regression, the washout rate did not significantly correlate with the presence of ischemic heart disease ( p = 0.254); in a multivariate regression, the presence of ischemic heart disease did not predict the washout rate. For the 14 patients with sinus rhythm, there was a marginal negative correlation between the E / A velocity ratio of the transmitral flow and washout rate (standardized correlation coefficient = − 0.518, p < 0.07). In diastolic heart failure, cardiac sympathetic nerve activity increases proportionally to severity of the disease.