Surfactant Function and Composition in Premature Infants Treated With Inhaled Nitric Oxide

We hypothesized that inhaled nitric oxide treatment of premature infants at risk for bronchopulmonary dysplasia would not adversely affect endogenous surfactant function or composition. As part of the Nitric Oxide Chronic Lung Disease Trial of inhaled nitric oxide, we examined surfactant in a subpop...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2007-08, Vol.120 (2), p.346-353
Main Authors: Ballard, Philip L, Merrill, Jeffrey D, Truog, William E, Godinez, Rodolfo I, Godinez, Marye H, McDevitt, Theresa M, Ning, Yue, Golombek, Sergio G, Parton, Lance A, Luan, Xianqun, Cnaan, Avital, Ballard, Roberta A
Format: Article
Language:English
Subjects:
Administration, Inhalation
Analysis
Babies
Bronchopulmonary dysplasia
Bronchopulmonary Dysplasia - drug therapy
Bronchopulmonary Dysplasia - physiopathology
Bronchopulmonary Dysplasia - prevention & control
Cardiovascular disease
Care and treatment
Female
Health aspects
Humans
Infant, Newborn
Infant, Premature - physiology
Infants (Premature)
Lungs
Male
Nitric oxide
Nitric Oxide - administration & dosage
Pediatrics
Physiological aspects
Premature infants
Prevention
Pulmonary Alveoli - chemistry
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - physiology
Pulmonary surfactant
Pulmonary Surfactant-Associated Proteins - chemistry
Pulmonary Surfactant-Associated Proteins - physiology
Pulmonary surfactants
Surface Tension - drug effects
Surfactants
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Summary:We hypothesized that inhaled nitric oxide treatment of premature infants at risk for bronchopulmonary dysplasia would not adversely affect endogenous surfactant function or composition. As part of the Nitric Oxide Chronic Lung Disease Trial of inhaled nitric oxide, we examined surfactant in a subpopulation of enrolled infants. Tracheal aspirate fluid was collected at specified intervals from 99 infants with birth weights
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2007-0095