Serotonin transporter gene polymorphism (5-HTTLPR) in patients with oral lichen planus

Abstract Background Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter (5-HTT) may be involved in psychiatric alterations. Recent findings have demonstrated that depression and stress are influenced by polymorphism of the promoter region of 5-HTT (5-...

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Published in:Archives of oral biology 2007-09, Vol.52 (9), p.889-893
Main Authors: Perdigão, Paôlla Freitas, Guimarães, André Luiz Sena, Victoria, Junia Maria Netto, Xavier, Guilherme Machado, Romano-Silva, Marco Aurélio, Gomez, Ricardo Santiago
Format: Article
Language:English
Subjects:
5-HTTLPR
Adolescent
Adult
Advanced Basic Science
Aged
Alleles
Case-Control Studies
Dentistry
Female
Gene Frequency - genetics
Genotype
Humans
Lichen Planus, Oral - genetics
Male
Middle Aged
Oral lichen planus and stress
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Promoter Regions, Genetic - genetics
Risk Factors
Serotonin Plasma Membrane Transport Proteins - genetics
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Summary:Abstract Background Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter (5-HTT) may be involved in psychiatric alterations. Recent findings have demonstrated that depression and stress are influenced by polymorphism of the promoter region of 5-HTT (5-HTTLPR) and that the short allele (S) is associated with reduced transcriptional efficiency resulting in reduced serotonin expression and uptake. As psychiatric and genetic factors have been implicated in the pathogenesis of oral lichen planus (OLP), the purpose of the present study was to investigate 5-HTTLPR polymorphism in patients with OLP compared to control subjects. Subjects and methods Fifty-four subjects affected by OLP and 54 healthy volunteers were genotyped at 5-HTTLPR. The chi-squared test was used for statistical analysis. To investigate the association between the single nucleotide polymorphisms and risk of OLP, binary logistic regression models were fitted. Results No statistical difference was observed between the genotype and allele frequency in the group of OLP and controls ( p = 0.51). Moreover no association between 5HTTLPR alleles and OLP was found in the multivariate analyses. Conclusion Our study demonstrates that polymorphism on the 5-HTTLPR is not associated with OLP pathogenesis.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2007.02.001