Calcium gradients and the Golgi

Changes in intracellular free calcium regulate many intracellular processes. With respect to the secretory pathway and the Golgi apparatus, changes in calcium concentration occurring either in the adjacent cytosol or within the lumen of the Golgi act to regulate Golgi function. Conversely, the Golgi...

Full description

Saved in:
Bibliographic Details
Published in:Cell calcium (Edinburgh) 2006-11, Vol.40 (5), p.505-512
Main Authors: Dolman, Nick J., Tepikin, Alexei V.
Format: Article
Language:English
Subjects:
Animals
Calcium
Calcium Signaling - physiology
Calcium-Binding Proteins - metabolism
Golgi
Golgi Apparatus - drug effects
Golgi Apparatus - physiology
Inositol 1,4,5-Trisphosphate Receptors - metabolism
Mitochondria
Mitochondria - physiology
Pancreas
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Changes in intracellular free calcium regulate many intracellular processes. With respect to the secretory pathway and the Golgi apparatus, changes in calcium concentration occurring either in the adjacent cytosol or within the lumen of the Golgi act to regulate Golgi function. Conversely, the Golgi sequesters calcium to shape cytosolic calcium signals as well as initiate them by releasing calcium via inositol-1,4,5-triphosphate (IP 3) receptors, located on Golgi membranes. Local calcium transients juxtaposed to the Golgi (arising from release by the Golgi or other organelles) can activate calcium dependent signalling molecules located on or around the Golgi. This review focuses on the reciprocal relationship between the cell biology of the Golgi apparatus and intracellular calcium homeostasis.
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2006.08.012