CoREST-like complexes regulate chromatin modification and neuronal gene expression

The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2006-01, Vol.29 (3), p.227-240
Main Authors: Lakowski, Bernard, Roelens, Ingele, Jacob, Sandrine
Format: Article
Language:English
Subjects:
Animals
Arabidopsis Proteins - physiology
Biological Evolution
Caenorhabditis elegans
Caenorhabditis elegans Proteins - physiology
Chromatin - genetics
Chromatin - metabolism
Co-Repressor Proteins
DNA-Binding Proteins - physiology
Drosophila melanogaster
Drosophila Proteins - physiology
Epigenesis, Genetic
Gene expression
Gene Expression Regulation
Genetics
High Mobility Group Proteins - physiology
Histone Deacetylase 1
Histone Deacetylase 2
Histone Deacetylases - physiology
Histone Demethylases
Humans
Insects
Invertebrates - genetics
Invertebrates - metabolism
Mammals - genetics
Mammals - metabolism
Mice
Multiprotein Complexes - physiology
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Neurons - metabolism
Oxidoreductases, N-Demethylating - physiology
Promoter Regions, Genetic
Proteins
Proto-Oncogene Proteins c-raf - physiology
Repressor Proteins - physiology
Transcription Factors - physiology
Transcription, Genetic - physiology
Xenopus laevis
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Description
Summary:The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate. Components of a CoREST-like complex have been identified recently in Xenopus laevis, Caenorhabditis elegans, and Drosophila melanogaster. Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression.
ISSN:0895-8696
0895-8696
1559-1166
DOI:10.1385/JMN:29:3:227